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- W2766504538 abstract "Abstract Host immunity exerts strong selection on pathogens, but it does not act in a uniform manner across individual hosts. By providing a direct approach for understanding host-specific selection pressures, patterns of intra-host pathogen diversity complement population genetic analyses performed on broad geographic scales. Here, we perform a combined analysis of inter- and intra-host diversity for the malaria parasite Plasmodium falciparum with haplotype sequences of three antigens sampled from over 4,500 natural infections in sub-Saharan Africa using targeted deep sequencing. We find that multi-strain infections in young children contain non-random combinations of parasite genotypes, and identify individual amino acid positions that may contribute to strain-specific blocking of infections. These results demonstrate for the first time that natural host defenses to Plasmodium detectably impact which infections proceed to the blood stage within a given host. This selection partially explains the extreme amino acid diversity observed at many parasite antigens and suggests that vaccines targeting such proteins should account for the impact of allele-specific immunity." @default.
- W2766504538 created "2017-11-10" @default.
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- W2766504538 date "2017-11-01" @default.
- W2766504538 modified "2023-09-26" @default.
- W2766504538 title "Within-infection diversity of<i>Plasmodium falciparum</i>antigens reflects host-mediated selection" @default.
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- W2766504538 doi "https://doi.org/10.1101/212209" @default.
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