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- W2766504911 abstract "Ubiquitin-like containing plant homeodomain and RING finger domains 1 (UHRF1) is an anti-apoptotic protein involved in the silencing of several tumor suppressor genes (TSGs) through epigenetic modifications including DNA methylation and histone post-translational alterations, and also epigenetic-independent mechanisms. UHRF1 overexpression is observed in a number of solid tumors and hematological malignancies, and is considered a primary mechanism in inhibiting apoptosis. UHRF1 exerts its inhibitory activity on TSGs by binding to functional domains and therefore influences several epigenetic actors including DNA methyltransferase, histone deacetylase 1, histone acetyltransferase Tat-interacting protein 60 and histone methyltransferases G9a and Suv39H1. UHRF1 is considered to control a large macromolecular protein complex termed epigenetic code replication machinery, in order to maintain epigenetic silencing of TSGs during cell division, thus enabling cancer cells to escape apoptosis. MicroRNAs (miRNAs) are able to regulate the expression of its target gene by functioning as either an oncogene or a tumor suppressor. In the present review, the role of tumor suppressive miRNAs in the regulation of UHRF1, and the importance of targeting the microRNA/UHRF1 pathways in order to induce the reactivation of silenced TSGs and subsequent apoptosis are discussed." @default.
- W2766504911 created "2017-11-10" @default.
- W2766504911 creator A5019665090 @default.
- W2766504911 creator A5038109335 @default.
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- W2766504911 creator A5052176501 @default.
- W2766504911 creator A5052591989 @default.
- W2766504911 creator A5052734823 @default.
- W2766504911 creator A5086147319 @default.
- W2766504911 date "2017-10-30" @default.
- W2766504911 modified "2023-10-18" @default.
- W2766504911 title "Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)" @default.
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