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• W2766509541 startingPage "1069" @default.
• W2766509541 abstract "Introduction: Elderly patients with chronic lymphocytic leukemia (CLL) or patients with comorbidities are often treated with chlorambucil (Chl) as front-line therapy despite relatively low response rates. The addition of a monoclonal anti-CD20 antibody to Chl substantially increases response rates and prolongs progression-free survival (PFS) in these patients, without increasing toxicity. As a result, the ESMO guidelines recommend that previously untreated CLL patients with relevant co-morbidity, but without TP53 deletion/mutation, should be treated with the combination of Chl plus an anti-CD20 antibody (rituximab, ofatumumab or obinutuzumab).Areas covered: This review focuses on the treatment approach of elderly and unfit patients with untreated chronic lymphocytic leukemia.Expert commentary: The addition of a monoclonal anti-CD20 antibody to Chl is currently the suggested treatment in this subset of CLL patients. The choice of the anti-CD20 antibody remains an open question, although obinutuzumab was found to be superior to rituximab, in a head-to-head comparison of Chl-based combinations, in untreated CLL patients with comorbidities, with higher progression free survival, complete remission rates and minimal residual disease-negative remissions. Because patients with a TP53 deletion/mutation are resistant to chemo-immunotherapy, treatment with the BTK inhibitor ibrutinib is recommended in this setting." @default.
• W2766509541 created "2017-11-10" @default.
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• W2766509541 date "2017-11-03" @default.
• W2766509541 modified "2023-10-01" @default.
• W2766509541 title "Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia" @default.
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• W2766509541 doi "https://doi.org/10.1080/17474086.2017.1398642" @default.
• W2766509541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29082795" @default.
• W2766509541 hasPublicationYear "2017" @default.
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