FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766553630> ?p ?o ?g. }

• W2766553630 endingPage "269" @default.
• W2766553630 startingPage "243" @default.
• W2766553630 abstract "CRISPR-Cas (CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats and Cas: CRISPR associated) systems are unique defence mechanisms since they are able to adapt to new invaders and are heritable. CRISPR-Cas systems facilitate the sequence-specific elimination of invading genetic elements in prokaryotes, they are found in 45% of bacteria and 85% of archaea. Their general features have been studied in detail, but subtype- and species-specific variations await investigation. Haloarchaea is one of few archaeal classes in which CRISPR-Cas systems have been investigated in more than one genus. Here, we summarize the available information on CRISPR-Cas defence in three Haloarchaea: Haloferax volcanii, Haloferax mediterranei and Haloarcula hispanica. Haloarchaea share type I CRISPR-Cas systems, with subtype I-B being dominant. Type I-B systems rely on Cas proteins Cas5, Cas7, and Cas8b for the interference reaction and these proteins have been shown to form a Cascade (CRISPR-associated complex for antiviral defence) -like complex in Hfx (Haloferax). volcanii. Cas6b is the endonuclease for crRNA (CRISPR RNA) maturation in type I-B systems but the protein is dispensable for interference in Hfx. volcanii. Haloarchaea share a common repeat sequence and crRNA-processing pattern. A prerequisite for successful invader recognition in Hfx. volcanii is base pairing over a ten-nucleotide-long non-contiguous seed sequence. Moreover, Hfx. volcanii and Har (Haloarcula). hispanica rely each on certain specific PAM (protospacer adjacent motif) sequences to elicit interference, but they share only one PAM sequence. Primed adaptation in Har. hispanica relies on another set of PAM sequences." @default.
• W2766553630 created "2017-11-10" @default.
• W2766553630 creator A5008400965 @default.
• W2766553630 creator A5017672883 @default.
• W2766553630 creator A5048162129 @default.
• W2766553630 creator A5076006088 @default.
• W2766553630 date "2017-01-01" @default.
• W2766553630 modified "2023-09-23" @default.
• W2766553630 title "CRISPR and Salty: CRISPR-Cas Systems in Haloarchaea" @default.
• W2766553630 cites W106604041 @default.
• W2766553630 cites W1495583714 @default.
• W2766553630 cites W1507470692 @default.
• W2766553630 cites W1552724685 @default.
• W2766553630 cites W1885752046 @default.
• W2766553630 cites W1966143331 @default.
• W2766553630 cites W1970733967 @default.
• W2766553630 cites W1977429572 @default.
• W2766553630 cites W1978094899 @default.
• W2766553630 cites W1978942464 @default.
• W2766553630 cites W1986171241 @default.
• W2766553630 cites W1990487336 @default.
• W2766553630 cites W2000132134 @default.
• W2766553630 cites W2001199457 @default.
• W2766553630 cites W2004317124 @default.
• W2766553630 cites W2005328221 @default.
• W2766553630 cites W2006494972 @default.
• W2766553630 cites W2010986636 @default.
• W2766553630 cites W2019197162 @default.
• W2766553630 cites W2022125381 @default.
• W2766553630 cites W2024303950 @default.
• W2766553630 cites W2029467110 @default.
• W2766553630 cites W2031753266 @default.
• W2766553630 cites W2035755224 @default.
• W2766553630 cites W2036281635 @default.
• W2766553630 cites W2039375385 @default.
• W2766553630 cites W2045435533 @default.
• W2766553630 cites W2052192736 @default.
• W2766553630 cites W2062008243 @default.
• W2766553630 cites W2067431944 @default.
• W2766553630 cites W2069534672 @default.
• W2766553630 cites W2071195434 @default.
• W2766553630 cites W2074862753 @default.
• W2766553630 cites W2077190448 @default.
• W2766553630 cites W2094958519 @default.
• W2766553630 cites W2101007869 @default.
• W2766553630 cites W2108101601 @default.
• W2766553630 cites W2110399041 @default.
• W2766553630 cites W2112197977 @default.
• W2766553630 cites W2120546567 @default.
• W2766553630 cites W2131552409 @default.
• W2766553630 cites W2132440004 @default.
• W2766553630 cites W2135598273 @default.
• W2766553630 cites W2138116029 @default.
• W2766553630 cites W2143584004 @default.
• W2766553630 cites W2143772974 @default.
• W2766553630 cites W2149635735 @default.
• W2766553630 cites W2149751339 @default.
• W2766553630 cites W2153355254 @default.
• W2766553630 cites W2153650494 @default.
• W2766553630 cites W2158266834 @default.
• W2766553630 cites W2166139447 @default.
• W2766553630 cites W2169244146 @default.
• W2766553630 cites W2199695484 @default.
• W2766553630 cites W2397372517 @default.
• W2766553630 cites W2405625753 @default.
• W2766553630 cites W2470979746 @default.
• W2766553630 cites W2502856725 @default.
• W2766553630 cites W2529324599 @default.
• W2766553630 cites W2563361853 @default.
• W2766553630 cites W30058334 @default.
• W2766553630 cites W4245109835 @default.
• W2766553630 doi "https://doi.org/10.1007/978-3-319-65795-0_11" @default.
• W2766553630 hasPublicationYear "2017" @default.
• W2766553630 type Work @default.
• W2766553630 sameAs 2766553630 @default.
• W2766553630 citedByCount "2" @default.
• W2766553630 countsByYear W27665536302019 @default.
• W2766553630 countsByYear W27665536302020 @default.
• W2766553630 crossrefType "book-chapter" @default.
• W2766553630 hasAuthorship W2766553630A5008400965 @default.
• W2766553630 hasAuthorship W2766553630A5017672883 @default.
• W2766553630 hasAuthorship W2766553630A5048162129 @default.
• W2766553630 hasAuthorship W2766553630A5076006088 @default.
• W2766553630 hasConcept C104317684 @default.
• W2766553630 hasConcept C2776179084 @default.
• W2766553630 hasConcept C2779926853 @default.
• W2766553630 hasConcept C44667518 @default.
• W2766553630 hasConcept C523546767 @default.
• W2766553630 hasConcept C54355233 @default.
• W2766553630 hasConcept C550995028 @default.
• W2766553630 hasConcept C70721500 @default.
• W2766553630 hasConcept C84356384 @default.
• W2766553630 hasConcept C86803240 @default.
• W2766553630 hasConcept C98108389 @default.
• W2766553630 hasConceptScore W2766553630C104317684 @default.
• W2766553630 hasConceptScore W2766553630C2776179084 @default.
• W2766553630 hasConceptScore W2766553630C2779926853 @default.
• W2766553630 hasConceptScore W2766553630C44667518 @default.

• next