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- W2766568093 endingPage "166" @default.
- W2766568093 startingPage "159" @default.
- W2766568093 abstract "Four decades ago, two staging systems were developed to help stratify CLL into different prognostic categories. These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia. Better understanding of biologic, genetic, and molecular characteristics of CLL have contributed to better appreciating its clinical heterogeneity. New prognostic models, the GCLLSG prognostic index and the CLL-IPI, emerged. They incorporate biologic and genetic information related to CLL and are capable of predicting survival outcomes and cases anticipated to need therapy earlier in the disease course. Accordingly, these newer models are helping develop better informed surveillance strategies and ultimately tailor treatment intensity according to presence (or lack thereof) of certain prognostic markers. This represents a step towards personalizing care of CLL patients. We anticipate that as more prognostic factors continue to be identified, the GCLLSG prognostic index and CLL-IPI models will undergo further revisions." @default.
- W2766568093 created "2017-11-10" @default.
- W2766568093 creator A5017327825 @default.
- W2766568093 creator A5046337431 @default.
- W2766568093 creator A5059854479 @default.
- W2766568093 creator A5060360947 @default.
- W2766568093 creator A5065364553 @default.
- W2766568093 creator A5083280695 @default.
- W2766568093 date "2018-03-01" @default.
- W2766568093 modified "2023-10-05" @default.
- W2766568093 title "Using prognostic models in CLL to personalize approach to clinical care: Are we there yet?" @default.
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