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• W2766569892 abstract "The promoter region of the telomerase reverse transcriptase gene (TERT) is mutated in a subpopulation of patients with glioblastoma multiforme (GBM). In the present study, preclinical and clinical implications of the mutation were analyzed in 25 GBMs to evaluate its utility as a therapeutic target. Associations between the TERT promoter mutation and a number of preclinical/clinical characteristics were analyzed. Notably, the TERT promoter mutation was identified in 92.3% of GBMs where dissociated cells revealed in vitro sphere formation capacity; while the TERT promoter mutation was identified in 33.3% of GBMs without in vitro sphere formation capacity (P=0.004). In addition, this significantly increased mutation rate was observed in GBMs with in vivo tumorigenic potential (80% vs. 0%; P=0.004). Furthermore, patients with GBM exhibiting the TERT promoter mutation demonstrated significantly decreased overall survival rate compared with patients lacking this mutation (81.7 vs. 152.6 weeks; P=0.026). The results of the present study indicated that the TERT promoter mutation is associated with the self-renewal capacity of GBM cells and clinical aggressiveness of GBMs, which may be translated to a targeting therapy against TERT to inhibit the self-renewal of GBM cells." @default.
• W2766569892 created "2017-11-10" @default.
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• W2766569892 date "2017-10-16" @default.
• W2766569892 modified "2023-10-01" @default.
• W2766569892 title "Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme" @default.
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• W2766569892 doi "https://doi.org/10.3892/ol.2017.7196" @default.
• W2766569892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5755188" @default.
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