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• W2766586999 abstract "Abstract Blocking the interaction between Programmed Death Ligand 1 (PD-L1) and its receptor, PD-1, is an effective method of treating many types of cancers. Certain tumors overexpress PD-L1, causing host immune cells that express PD-1 to bind PD-L1 and cease killing the tumor. Inhibition of PD-L1 and PD-1 binding can restore host immunity towards tumor killing, and many new drugs have been developed to target this interaction. Current methods of PD-L1 diagnosis have shown to vary based on the antibody, detection kit brand, antigen retrieval method, and clinically defined methods by the FDA. To refine detection of PD-L1, we have identified a peptide, RK-10, and used it to detect PD-L1 expressing tumors with immunohistochemistry or flow cytometry. Flow cytometry was performed on cell lines and patient tissues using a fluorescent peptide (RK-10-Cy5). Immunohistochemistry using a biotin-modified peptide (RK-10-Biotin) was tested against the FDA-approved SP263 clone on biopsied patient tissues. For this study, we evaluated specificity of RK-10 using IHC in over 200 patient tissues, including NSCLC and Hodgkin’s Lymphoma. RK-10 shows staining in the tumor regions of FFPE tissues where the SP263 kit does not. RK-10-Cy5 peptide also demonstrates PD-L1 detection in NSCLC, breast, squamous cell carcinoma, and melanoma." @default.
• W2766586999 created "2017-11-10" @default.
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• W2766586999 date "2017-10-20" @default.
• W2766586999 modified "2023-10-10" @default.
• W2766586999 title "Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors" @default.
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• W2766586999 doi "https://doi.org/10.1038/s41598-017-10946-2" @default.
• W2766586999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5651871" @default.
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