Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766587424> ?p ?o ?g. }
- W2766587424 abstract "We investigated clinical and genetic characteristics of high-risk follicular lymphoma (FL), that lacked evidence of large cell transformation at diagnosis, in the rituximab era. First, we retrospectively analysed the clinical features of 100 patients with non-transformed FL that were consecutively treated with rituximab-containing therapies in a discovery cohort. The presence of either peripheral blood and/or bone involvement was associated with short progression-free survival. This was confirmed in a validation cohort of 66 FL patients. Then, whole exome sequencing was performed on randomly selected 5 high- and 9 standard-risk FL tumours. The most common mutational signature was a CG > TG substitution-enriched signature associated with spontaneous deamination of 5-methylcytosine at CpG, but mutations in WA and WRC(Y) motifs (so-called activation-induced cytidine deaminase (AID) motifs) were also enriched throughout the whole exome. We found clustered mutations in target sequences of AID in the IG and BCL2 loci. Importantly, high-risk FLs harboured more somatic mutations (mean 190 vs. 138, P = 0.04), including mutations in WA (33 vs. 22, P = 0.038), WRC (34 vs. 22, P = 0.016) and WRCY motifs (17 vs. 11, P = 0.004). These results suggest that genomic instability that allows for emergence of distinct mutations through AID activity underlies development of the high-risk FL phenotype." @default.
- W2766587424 created "2017-11-10" @default.
- W2766587424 creator A5010174858 @default.
- W2766587424 creator A5015226868 @default.
- W2766587424 creator A5015449116 @default.
- W2766587424 creator A5016541702 @default.
- W2766587424 creator A5018608174 @default.
- W2766587424 creator A5028457340 @default.
- W2766587424 creator A5036112859 @default.
- W2766587424 creator A5039257959 @default.
- W2766587424 creator A5043335646 @default.
- W2766587424 creator A5044994496 @default.
- W2766587424 creator A5054667160 @default.
- W2766587424 creator A5056413703 @default.
- W2766587424 creator A5061482148 @default.
- W2766587424 creator A5070028777 @default.
- W2766587424 creator A5072434041 @default.
- W2766587424 creator A5075602799 @default.
- W2766587424 creator A5076540249 @default.
- W2766587424 date "2017-10-25" @default.
- W2766587424 modified "2023-10-17" @default.
- W2766587424 title "High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif" @default.
- W2766587424 cites W1529282476 @default.
- W2766587424 cites W1554787345 @default.
- W2766587424 cites W1580707139 @default.
- W2766587424 cites W1970648523 @default.
- W2766587424 cites W1973686119 @default.
- W2766587424 cites W1975272871 @default.
- W2766587424 cites W1977295792 @default.
- W2766587424 cites W1984315693 @default.
- W2766587424 cites W1985389664 @default.
- W2766587424 cites W1991589385 @default.
- W2766587424 cites W1992915563 @default.
- W2766587424 cites W2003262666 @default.
- W2766587424 cites W2005485091 @default.
- W2766587424 cites W2022748041 @default.
- W2766587424 cites W2028056951 @default.
- W2766587424 cites W2028578415 @default.
- W2766587424 cites W2042652801 @default.
- W2766587424 cites W2054730264 @default.
- W2766587424 cites W2059145105 @default.
- W2766587424 cites W2059698538 @default.
- W2766587424 cites W2090505632 @default.
- W2766587424 cites W2096367579 @default.
- W2766587424 cites W2097050657 @default.
- W2766587424 cites W2101648653 @default.
- W2766587424 cites W2108131857 @default.
- W2766587424 cites W2129200400 @default.
- W2766587424 cites W2132135544 @default.
- W2766587424 cites W2138601221 @default.
- W2766587424 cites W2141681661 @default.
- W2766587424 cites W2143238378 @default.
- W2766587424 cites W2146290346 @default.
- W2766587424 cites W2148687964 @default.
- W2766587424 cites W2152162065 @default.
- W2766587424 cites W2154643481 @default.
- W2766587424 cites W2155943701 @default.
- W2766587424 cites W2160093471 @default.
- W2766587424 cites W2165608602 @default.
- W2766587424 cites W2277606729 @default.
- W2766587424 cites W2464635942 @default.
- W2766587424 cites W2559869208 @default.
- W2766587424 cites W2561792671 @default.
- W2766587424 cites W2953163445 @default.
- W2766587424 cites W4293203547 @default.
- W2766587424 doi "https://doi.org/10.1038/s41598-017-14150-0" @default.
- W2766587424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5656578" @default.
- W2766587424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29070849" @default.
- W2766587424 hasPublicationYear "2017" @default.
- W2766587424 type Work @default.
- W2766587424 sameAs 2766587424 @default.
- W2766587424 citedByCount "10" @default.
- W2766587424 countsByYear W27665874242018 @default.
- W2766587424 countsByYear W27665874242019 @default.
- W2766587424 countsByYear W27665874242020 @default.
- W2766587424 countsByYear W27665874242021 @default.
- W2766587424 countsByYear W27665874242022 @default.
- W2766587424 crossrefType "journal-article" @default.
- W2766587424 hasAuthorship W2766587424A5010174858 @default.
- W2766587424 hasAuthorship W2766587424A5015226868 @default.
- W2766587424 hasAuthorship W2766587424A5015449116 @default.
- W2766587424 hasAuthorship W2766587424A5016541702 @default.
- W2766587424 hasAuthorship W2766587424A5018608174 @default.
- W2766587424 hasAuthorship W2766587424A5028457340 @default.
- W2766587424 hasAuthorship W2766587424A5036112859 @default.
- W2766587424 hasAuthorship W2766587424A5039257959 @default.
- W2766587424 hasAuthorship W2766587424A5043335646 @default.
- W2766587424 hasAuthorship W2766587424A5044994496 @default.
- W2766587424 hasAuthorship W2766587424A5054667160 @default.
- W2766587424 hasAuthorship W2766587424A5056413703 @default.
- W2766587424 hasAuthorship W2766587424A5061482148 @default.
- W2766587424 hasAuthorship W2766587424A5070028777 @default.
- W2766587424 hasAuthorship W2766587424A5072434041 @default.
- W2766587424 hasAuthorship W2766587424A5075602799 @default.
- W2766587424 hasAuthorship W2766587424A5076540249 @default.
- W2766587424 hasBestOaLocation W27665874241 @default.
- W2766587424 hasConcept C104317684 @default.
- W2766587424 hasConcept C126322002 @default.
- W2766587424 hasConcept C127716648 @default.
- W2766587424 hasConcept C128526571 @default.