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- W2766637427 abstract "Cellular transformation owing to cigarette smoking is due to chronic exposure and not acute. However, systematic studies to understand the molecular alterations in lung cells due to cigarette smoke are lacking. To understand these molecular alterations induced by chronic cigarette smoke exposure, we carried out tandem mass tag (TMT) based temporal proteomic profiling of lung cells exposed to cigarette smoke for upto 12 months. We identified 2620 proteins in total, of which 671 proteins were differentially expressed (1.5-fold) after 12 months of exposure. Prolonged exposure of lung cells to smoke for 12 months revealed dysregulation of oxidative phosphorylation and overexpression of enzymes involved in TCA cycle. In addition, we also observed overexpression of enzymes involved in glutamine metabolism, fatty acid degradation and lactate synthesis. This could possibly explain the availability of alternative source of carbon to TCA cycle apart from glycolytic pyruvate. Our data indicates that chronic exposure to cigarette smoke induces mitochondrial metabolic reprogramming in cells to support growth and survival." @default.
- W2766637427 created "2017-11-10" @default.
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- W2766637427 date "2018-05-01" @default.
- W2766637427 modified "2023-10-14" @default.
- W2766637427 title "Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells" @default.
- W2766637427 cites W1191133043 @default.
- W2766637427 cites W153904168 @default.
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- W2766637427 cites W1581077481 @default.
- W2766637427 cites W1600645745 @default.
- W2766637427 cites W1756746938 @default.
- W2766637427 cites W1797058518 @default.
- W2766637427 cites W1972814371 @default.
- W2766637427 cites W1977667938 @default.
- W2766637427 cites W1978741366 @default.
- W2766637427 cites W1980193327 @default.
- W2766637427 cites W1982330633 @default.
- W2766637427 cites W1983612848 @default.
- W2766637427 cites W1985066215 @default.
- W2766637427 cites W1987581195 @default.
- W2766637427 cites W1990811092 @default.
- W2766637427 cites W1992978140 @default.
- W2766637427 cites W1993006648 @default.
- W2766637427 cites W1995407474 @default.
- W2766637427 cites W1997099893 @default.
- W2766637427 cites W2008834310 @default.
- W2766637427 cites W2010559315 @default.
- W2766637427 cites W2010585604 @default.
- W2766637427 cites W2010853051 @default.
- W2766637427 cites W2011137726 @default.
- W2766637427 cites W2016535776 @default.
- W2766637427 cites W2021750913 @default.
- W2766637427 cites W2024250498 @default.
- W2766637427 cites W2025941955 @default.
- W2766637427 cites W2026403707 @default.
- W2766637427 cites W2034400796 @default.
- W2766637427 cites W2037199116 @default.
- W2766637427 cites W2040234043 @default.
- W2766637427 cites W2045263357 @default.
- W2766637427 cites W2046267064 @default.
- W2766637427 cites W2052543023 @default.
- W2766637427 cites W2052655719 @default.
- W2766637427 cites W2056055010 @default.
- W2766637427 cites W2058807219 @default.
- W2766637427 cites W2075084694 @default.
- W2766637427 cites W2076782790 @default.
- W2766637427 cites W2079487663 @default.
- W2766637427 cites W2089028313 @default.
- W2766637427 cites W2090406819 @default.
- W2766637427 cites W2093005884 @default.
- W2766637427 cites W2099810479 @default.
- W2766637427 cites W2103409364 @default.
- W2766637427 cites W2105711725 @default.
- W2766637427 cites W2106406160 @default.
- W2766637427 cites W2110015442 @default.
- W2766637427 cites W2113651620 @default.
- W2766637427 cites W2117975450 @default.
- W2766637427 cites W2118538747 @default.
- W2766637427 cites W2122863289 @default.
- W2766637427 cites W2125660831 @default.
- W2766637427 cites W2128200303 @default.
- W2766637427 cites W2142265048 @default.
- W2766637427 cites W2142817949 @default.
- W2766637427 cites W2146653132 @default.
- W2766637427 cites W2147048296 @default.
- W2766637427 cites W2147539132 @default.
- W2766637427 cites W2154409238 @default.
- W2766637427 cites W2154417913 @default.
- W2766637427 cites W2154802086 @default.
- W2766637427 cites W2161960558 @default.
- W2766637427 cites W2165642864 @default.
- W2766637427 cites W2166478007 @default.
- W2766637427 cites W2169244300 @default.
- W2766637427 cites W2180760460 @default.
- W2766637427 cites W2337353829 @default.
- W2766637427 cites W2410940540 @default.
- W2766637427 cites W2463195069 @default.
- W2766637427 cites W2473634482 @default.
- W2766637427 cites W2486966814 @default.
- W2766637427 cites W2512054374 @default.
- W2766637427 cites W2541542137 @default.
- W2766637427 cites W2547187744 @default.
- W2766637427 cites W2553304061 @default.
- W2766637427 cites W2554984004 @default.