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- W2766645333 abstract "Significance CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) is an E3 ubiquitin ligase acting as a central repressor of seedling photomorphogenesis in plants. Many nuclear-localized COP1 substrates have been identified in the last two decades; however, whether COP1 targets cytoplasmic factors for ubiquitination and degradation remains largely unknown. In this study, we show that COP1 interacts with a microtubule-associated protein, WAVE-DAMPENED 2-LIKE 3 (WDL3), in a dark-dependent manner at cortical microtubules. Thus, COP1 targets WDL3 for 26S proteasome-mediated degradation to control hypocotyl elongation in etiolated Arabidopsis seedlings. Collectively, our study uncovers a cytoplasmic substrate of COP1 that functions as a microtubule-associated protein in mediating hypocotyl cell elongation." @default.
- W2766645333 created "2017-11-10" @default.
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- W2766645333 date "2017-10-30" @default.
- W2766645333 modified "2023-09-26" @default.
- W2766645333 title "COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating <i>Arabidopsis</i> hypocotyl elongation" @default.
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- W2766645333 doi "https://doi.org/10.1073/pnas.1708087114" @default.
- W2766645333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5699047" @default.
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