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• W2766651195 endingPage "37" @default.
• W2766651195 startingPage "27" @default.
• W2766651195 abstract "Pemphigus is a severe autoimmune blistering disease mediated by pathogenic anti-desmoglein antibodies leading to an inter keratinocyte disjunction. Rituximab is a monoclonal antibody that binds to the CD-20 antigen of B lymphocytes, which causes B-cell depletion and a subsequent reduction in pathogenic autoantibodies. Its therapeutic role in pemphigus has been progressively growing with increasing evidence of successful outcomes. Rituximab was initially off-labeled used as an alternative in patients with recalcitrant or relapsing pemphigus and in patients with contraindications to systemic corticosteroids. Recently, a large randomized clinical trial has shown that first-line use of rituximab combined with short-term prednisone regimen was both more effective and potentially safer than a standard regimen of high doses of corticosteroids in patients with moderate to severe pemphigus." @default.
• W2766651195 created "2017-11-10" @default.
• W2766651195 creator A5050985511 @default.
• W2766651195 creator A5058334077 @default.
• W2766651195 date "2018-01-01" @default.
• W2766651195 modified "2023-10-13" @default.
• W2766651195 title "Rituximab in pemphigus" @default.
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