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• W2766654495 abstract "Early identification of those most at risk for dementia is a growing priority. The ability to walk while performing a cognitive task (i.e. dual-task walking) is impaired in adults with mild cognitive impairment (MCI) or dementia. Poorer dual-task performance may indicate underlying neuropathology and higher risk for dementia. However, no studies have assessed the longitudinal association between poorer dual-task walking, markers of neuropathology, and risk of dementia. We analyzed longitudinal data in older adults with Modified Mini-Mental State scores ≥80 (n=76; mean age= 78, 51% female, 33% black) who walked with and without a simultaneous visual-spatial task. Dual-task cost was calculated as change in gait speed from single-task to dual-task walking as a percentage of single-task gait speed. Participants underwent magnetic resonance imaging (MRI) in years 4 and 8 with cognitive adjudication in year 8. Grey matter volume of right and left hippocampus and annualized change in hippocampal volume were calculated from MRI. Cognitive impairment was defined as MCI or dementia at adjudication. Odds ratios (OR) and 95% confidence intervals were calculated as risk for cognitive impairment based on dual-task cost and adjusted for age, race, sex, and education. Additional adjustment by change in hippocampal volumes was conducted. After 8 years, 40/76 participants were cognitively impaired (53%). Higher dual-task cost (e.g. greater decline in speed with addition of visual-spatial task) was associated with greater odds of cognitive impairment at 8 years, both before (OR per 1% increase in dual task cost=1.08 (1.01, 1.15)) and after (OR=1.08 (1.01, 1.16)) adjustment for demographics. Greater annualized decline in gray matter volume attenuated the association of dual task cost with cognitive impairment for both left (OR=1.05 (0.85, 1.28)) and right (OR=1.01 (0.94, 1.09)) hippocampus. In this group of high functioning older adults, greater declines in gait speed while dual-tasking predicted greater risk for cognitive impairment 8 years later. Faster hippocampal atrophy may be an important neurobiological correlate that could explain this association. Dual-task walking may serve as a stress test on central nervous system resources and could provide an early clinical indicator for increased dementia risk." @default.
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• W2766654495 date "2017-07-01" @default.
• W2766654495 modified "2023-09-27" @default.
• W2766654495 title "[P4-335]: DUAL-TASK WALKING AS A PREDICTOR FOR LATER COGNITIVE IMPAIRMENT" @default.
• W2766654495 doi "https://doi.org/10.1016/j.jalz.2017.06.2205" @default.
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