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• W2766657220 abstract "Patients with Sjögren's syndrome (SS) are prone to develop malignant lymphomas, and a correlation has been established between the lymphoproliferations occurring in these disorders and the presence in patients' blood of an unusual B cell population that down-regulates complement receptor 2/CD21. This study was undertaken to identify the B cell compartment from which these lymphoproliferations emerge and determine the mechanisms that promote clonal B cell expansion in patients with SS.The reactivity of antibodies expressed by CD19+CD10-CD27-IgM+CD21-/low cells isolated from the blood of patients with SS was tested using a polymerase chain reaction-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by single B cells.Clonal expansions were identified in CD21-/low B cells isolated from the peripheral blood of 3 patients with SS. These lymphoproliferations expressed B cell receptors (BCRs) that displayed somatic hypermutation lineage trees characteristic of a strong selection by antigens; one of these antigens was identified as a ribosomal self antigen. When the mutated BCR sequences expressed by the expanded CD21-/low B cell clones from patients with SS were reverted in vitro to their germline counterparts, one clone remained autoreactive.Clonal lymphoproliferations in patients with SS preferentially accumulate in the autoreactive CD21-/low B cell compartment often expanded in these subjects, and recognition of self antigens may drive the clonal B cell expansion while further refining BCR self-reactivity." @default.
• W2766657220 created "2017-11-10" @default.
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• W2766657220 date "2018-01-18" @default.
• W2766657220 modified "2023-10-18" @default.
• W2766657220 title "Accumulation of Antigen‐Driven Lymphoproliferations in Complement Receptor 2/ <scp>CD</scp> 21 ^−/low B Cells From Patients With Sjögren's Syndrome" @default.
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• W2766657220 doi "https://doi.org/10.1002/art.40352" @default.
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• W2766657220 hasPublicationYear "2018" @default.
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