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- W2766678639 abstract "Hypoxia is a common characteristic of many types of solid tumors. Intratumoral hypoxia selects for tumor cells that survive in a low oxygen environment, undergo epithelial-mesenchymal transition, are more motile and invasive, and show gene expression changes driven by hypoxia-inducible factor-1α (HIF-1α) activation. Therefore, targeting HIF-1α is an attractive strategy for disrupting multiple pathways crucial for tumor growth. In the present study, we demonstrated that hypoxia increases the S-glutathionylation of HIF-1α and its protein levels in colon cancer cells. This effect is significantly prevented by decreasing oxidized glutathione as well as glutathione depletion, indicating that S-glutathionylation and the formation of protein-glutathione mixed disulfides is related to HIF-1α protein levels. Moreover, colon cancer cells expressing glutaredoxin 1 are resistant to inducing HIF-1α and expressing hypoxia-responsive genes under hypoxic conditions. Therefore, S-glutathionylation of HIF-1α induced by tumor hypoxia may be a novel therapeutic target for the development of new drugs." @default.
- W2766678639 created "2017-11-10" @default.
- W2766678639 creator A5004921983 @default.
- W2766678639 creator A5025995653 @default.
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- W2766678639 date "2018-01-01" @default.
- W2766678639 modified "2023-10-17" @default.
- W2766678639 title "Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells" @default.
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- W2766678639 doi "https://doi.org/10.1016/j.bbrc.2017.11.018" @default.
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