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• W2766680334 abstract "Alzheimer's disease (AD) pathology is characterized by the presence of amyloid (Aβ) plaques and neurofibrillary tangles. Physical activity (PA) has emerged as a possible modifier of these pathological changes associated with AD. Consequently, the aim of this study was to examine the relationship between objectively-measured PA and cerebrospinal fluid (CSF) levels of Aβ42 and tau in asymptomatic late-middle-aged adults at risk for AD. Fifty cognitively healthy late-middle-aged adults (age=63.17 years, 68.0% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They wore an accelerometer (ActiGraph GT3X+) for one week to record free-living PA. Accelerometer data yielded measures of sedentariness and various intensities of PA (i.e., light, moderate, and vigorous, determined according to well-established standards). Participants also underwent lumbar puncture for collection of CSF, from which Aβ42, total tau (t-tau) and phosphorylated tau (p-tau) were immunoassayed. We additionally computed tau-to-Aβ42 ratios. Regression analyses were utilized to examine the association between sedentariness/PA and CSF biomarkers, while adjusting for age, sex, apolipoprotein ε4 status, and interval between CSF collection and accelerometer data. Sedentariness was significantly associated with reduced Aβ42 (p=.023) and increased p-tau/Aβ42 (p=.018). Furthermore, engagement in moderate-intensity PA was significantly associated with higher Aβ42 (p=.002), lower t-tau/Aβ42 (p=.001), and lower p-tau/Aβ42 (p=.002). In contrast, neither light- nor vigorous-intensity PA was significantly associated with any of the biomarkers. The relationship between moderate-intensity PA and CSF biomarkers persisted (p=.009 for Aβ42; p=.008 for t-tau/Aβ42; and p=.003 for p-tau/Aβ42) even after accounting for time spent in light- and vigorous-intensity PA categories. In this cohort of late-middle-aged adults at risk for AD, sedentariness was associated with greater AD pathophysiology, while moderate-intensity PA was associated with a favorable biomarker profile. These findings are consistent with previous studies that suggest a physically active lifestyle may play a protective role against the development of AD." @default.
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• W2766680334 date "2017-07-01" @default.
• W2766680334 modified "2023-09-27" @default.
• W2766680334 title "[IC-P-171]: MODERATE INTENSITY PHYSICAL ACTIVITY ASSOCIATES WITH CSF BIOMARKERS IN PRECLINICAL ALZHEIMER's DISEASE" @default.
• W2766680334 doi "https://doi.org/10.1016/j.jalz.2017.06.2546" @default.
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