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- W2766684912 abstract "Some dietary patterns, in particular the Mediterranean diet, have been found to modulate the risk for cognitive decline and dementia in older adults. However, the contribution of specific nutritional components and their underlying biological mechanisms are not fully understood. Chronic pro-inflammatory states are known to facilitate neurodegenerative processes, and the composition of dietary lipids influences the balance between pro- and anti-inflammatory mediators. Evidence suggests opposite roles of polyunsaturated, long-chain omega-3 fatty acids (PUFA) and saturated fatty acids (SFA) with regards to promotion of pro- or anti-inflammatory states. We hypothesized that a high ratio of SFAs vs PUFAs would negatively affect cognitive performance and brain grey and white matter volumes in healthy individuals. 42 cognitively healthy older adults (age: 66±6,89 years) and 59 cognitively healthy younger subjects 24,98 ±4,07) were included into this study. Verbal memory was assessed using the California Verbal Learning Test (CVLT). Dietary intake of PUFA and SFA was calculated from food frequency questionnaire derived data (EPIC-FFQ). 3D-anatomical magnetic resonance imaging (MRI) data were obtained using a Siemens Trio 3T scanner. Grey and white matter volumes were assessed by voxel based morphometry (VBM) using SPM8. Bivariate correlations between the SFA/PUFA-ratio and neuropsychological test scores were calculated. Moreover, a multiple regression analyses using SFA/PUFA ratio, age, gender, education, body-mass-index, Apolipoprotein E-status and alcohol consumption as independent variables was conducted. For VBM data, a multiple regression analysis was performed using the same covariates as mentioned before with intracranial volume as additional covariate. A high SFA/PUFA-ratio was significantly (p < 0.05) related with poorer verbal memory performance (higher number of errors in the CVLT) and with lower white and grey matter volume in the left superior frontal gyrus (SFG), corresponding to Brodman areas BA6 and BA9. These findings support the hypothesis that a pro-inflammatory dietary fatty acid balance may promote neurodegeneration and negatively affect memory performance. Prospective longitudinal studies are needed to confirm these cross-sectional results." @default.
- W2766684912 created "2017-11-10" @default.
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- W2766684912 date "2017-07-01" @default.
- W2766684912 modified "2023-09-27" @default.
- W2766684912 title "[P4-367]: DIETARY FAT COMPOSITION CORRELATES WITH VERBAL MEMORY AND FRONTAL GREY AND WHITE MATTER VOLUME IN HEALTHY INDIVIDUALS: AN MRI STUDY" @default.
- W2766684912 doi "https://doi.org/10.1016/j.jalz.2017.06.2238" @default.
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