FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766700447> ?p ?o ?g. }

• W2766700447 abstract "The objective of this study was to investigate cellular bioenergetics in primary skin fibroblasts derived from patients with amyotrophic lateral sclerosis (ALS) and to determine if they can be used as classifiers for patient stratification. We assembled a collection of unprecedented size of fibroblasts from patients with sporadic ALS (sALS, n = 171), primary lateral sclerosis (PLS, n = 34), ALS/PLS with C9orf72 mutations (n = 13), and healthy controls (n = 91). In search for novel ALS classifiers, we performed extensive studies of fibroblast bioenergetics, including mitochondrial membrane potential, respiration, glycolysis, and ATP content. Next, we developed a machine learning approach to determine whether fibroblast bioenergetic features could be used to stratify patients. Compared to controls, sALS and PLS fibroblasts had higher average mitochondrial membrane potential, respiration, and glycolysis, suggesting that they were in a hypermetabolic state. Only membrane potential was elevated in C9Orf72 lines. ATP steady state levels did not correlate with respiration and glycolysis in sALS and PLS lines. Based on bioenergetic profiles, a support vector machine (SVM) was trained to classify sALS and PLS with 99% specificity and 70% sensitivity. sALS, PLS, and C9Orf72 fibroblasts share hypermetabolic features, while presenting differences of bioenergetics. The absence of correlation between energy metabolism activation and ATP levels in sALS and PLS fibroblasts suggests that in these cells hypermetabolism is a mechanism to adapt to energy dissipation. Results from SVM support the use of metabolic characteristics of ALS fibroblasts and multivariate analysis to develop classifiers for patient stratification." @default.
• W2766700447 created "2017-11-10" @default.
• W2766700447 creator A5000612299 @default.
• W2766700447 creator A5013611810 @default.
• W2766700447 creator A5021244706 @default.
• W2766700447 creator A5022326820 @default.
• W2766700447 creator A5024378459 @default.
• W2766700447 creator A5031853409 @default.
• W2766700447 creator A5041155016 @default.
• W2766700447 creator A5043533552 @default.
• W2766700447 creator A5067964335 @default.
• W2766700447 creator A5068204379 @default.
• W2766700447 creator A5070384343 @default.
• W2766700447 creator A5070593246 @default.
• W2766700447 creator A5072110668 @default.
• W2766700447 creator A5083309896 @default.
• W2766700447 date "2017-10-24" @default.
• W2766700447 modified "2023-10-18" @default.
• W2766700447 title "Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients" @default.
• W2766700447 cites W1722132302 @default.
• W2766700447 cites W1755032422 @default.
• W2766700447 cites W1927582128 @default.
• W2766700447 cites W1979358478 @default.
• W2766700447 cites W1980605405 @default.
• W2766700447 cites W1994079416 @default.
• W2766700447 cites W2006669716 @default.
• W2766700447 cites W2007336957 @default.
• W2766700447 cites W2012739537 @default.
• W2766700447 cites W2020225907 @default.
• W2766700447 cites W2038716961 @default.
• W2766700447 cites W2073987119 @default.
• W2766700447 cites W2082397844 @default.
• W2766700447 cites W2094963311 @default.
• W2766700447 cites W2109573140 @default.
• W2766700447 cites W2115125186 @default.
• W2766700447 cites W2130942676 @default.
• W2766700447 cites W2148704799 @default.
• W2766700447 cites W2149712320 @default.
• W2766700447 cites W2152352029 @default.
• W2766700447 cites W2152398366 @default.
• W2766700447 cites W2152954166 @default.
• W2766700447 cites W2154923701 @default.
• W2766700447 cites W2213750114 @default.
• W2766700447 cites W2317226401 @default.
• W2766700447 cites W2318160697 @default.
• W2766700447 cites W2319022464 @default.
• W2766700447 cites W2322683956 @default.
• W2766700447 cites W2346506765 @default.
• W2766700447 cites W2398660216 @default.
• W2766700447 cites W2414081692 @default.
• W2766700447 cites W2509029318 @default.
• W2766700447 cites W2509849114 @default.
• W2766700447 cites W2518689955 @default.
• W2766700447 cites W2534658966 @default.
• W2766700447 cites W2601417863 @default.
• W2766700447 cites W752817784 @default.
• W2766700447 doi "https://doi.org/10.1186/s13024-017-0217-5" @default.
• W2766700447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5655870" @default.
• W2766700447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29065921" @default.
• W2766700447 hasPublicationYear "2017" @default.
• W2766700447 type Work @default.
• W2766700447 sameAs 2766700447 @default.
• W2766700447 citedByCount "46" @default.
• W2766700447 countsByYear W27667004472018 @default.
• W2766700447 countsByYear W27667004472019 @default.
• W2766700447 countsByYear W27667004472020 @default.
• W2766700447 countsByYear W27667004472021 @default.
• W2766700447 countsByYear W27667004472022 @default.
• W2766700447 countsByYear W27667004472023 @default.
• W2766700447 crossrefType "journal-article" @default.
• W2766700447 hasAuthorship W2766700447A5000612299 @default.
• W2766700447 hasAuthorship W2766700447A5013611810 @default.
• W2766700447 hasAuthorship W2766700447A5021244706 @default.
• W2766700447 hasAuthorship W2766700447A5022326820 @default.
• W2766700447 hasAuthorship W2766700447A5024378459 @default.
• W2766700447 hasAuthorship W2766700447A5031853409 @default.
• W2766700447 hasAuthorship W2766700447A5041155016 @default.
• W2766700447 hasAuthorship W2766700447A5043533552 @default.
• W2766700447 hasAuthorship W2766700447A5067964335 @default.
• W2766700447 hasAuthorship W2766700447A5068204379 @default.
• W2766700447 hasAuthorship W2766700447A5070384343 @default.
• W2766700447 hasAuthorship W2766700447A5070593246 @default.
• W2766700447 hasAuthorship W2766700447A5072110668 @default.
• W2766700447 hasAuthorship W2766700447A5083309896 @default.
• W2766700447 hasBestOaLocation W27667004471 @default.
• W2766700447 hasConcept C100206155 @default.
• W2766700447 hasConcept C105702510 @default.
• W2766700447 hasConcept C142724271 @default.
• W2766700447 hasConcept C182215343 @default.
• W2766700447 hasConcept C20251656 @default.
• W2766700447 hasConcept C202751555 @default.
• W2766700447 hasConcept C2777464067 @default.
• W2766700447 hasConcept C2779134260 @default.
• W2766700447 hasConcept C2780381497 @default.
• W2766700447 hasConcept C2780596555 @default.
• W2766700447 hasConcept C28859421 @default.
• W2766700447 hasConcept C55493867 @default.
• W2766700447 hasConcept C62231903 @default.
• W2766700447 hasConcept C66517615 @default.
• W2766700447 hasConcept C71924100 @default.

• next