FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766700932> ?p ?o ?g. }

• W2766700932 endingPage "106947" @default.
• W2766700932 startingPage "106935" @default.
• W2766700932 abstract "Colorectal cancer (CRC)-associated mortality is primarily caused by lymph node (LN) and distant metastasis, highlighting the need for biomarkers that predict LN metastasis and facilitate better therapeutic strategies. We used an Isobaric Tags for Relative and Absolute Quantification (iTRAQ)-based comparative proteomics approach to identify novel biomarkers for predicting LN metastasis in CRC patients. We analyzed five paired samples of CRC with or without LN metastasis, adjacent normal mucosa, and normal colon mucosa, and differentially expressed proteins were identified and subsequently validated at the protein and/or mRNA levels by immunohistochemistry and qRT-PCR, respectively. We identified 55 proteins specifically associated with LN metastasis, from which we selected ezrin for further analysis and functional assessment. Expression of ezrin at both the protein and mRNA levels was significantly higher in CRC tissues than in adjacent normal colonic mucosa. In univariate analysis, high ezrin expression was significantly associated with tumor progression and poor prognosis, which was consistent with our in vitro findings that ezrin promotes the metastatic capacity of CRC cells by enabling cell invasion and migration. In multivariate analysis, high levels of ezrin protein and mRNA in CRC samples were independent predictors of LN metastasis. Our data thus identify ezrin as a novel protein and mRNA biomarker for predicting LN metastasis in CRC patients." @default.
• W2766700932 created "2017-11-10" @default.
• W2766700932 creator A5000966873 @default.
• W2766700932 creator A5002090011 @default.
• W2766700932 creator A5010023491 @default.
• W2766700932 creator A5017332423 @default.
• W2766700932 creator A5019440060 @default.
• W2766700932 creator A5020301050 @default.
• W2766700932 creator A5022107190 @default.
• W2766700932 creator A5028142206 @default.
• W2766700932 creator A5032801385 @default.
• W2766700932 creator A5033687873 @default.
• W2766700932 creator A5034105171 @default.
• W2766700932 creator A5036278151 @default.
• W2766700932 creator A5043978744 @default.
• W2766700932 creator A5047261124 @default.
• W2766700932 creator A5055195598 @default.
• W2766700932 creator A5062738958 @default.
• W2766700932 creator A5062920022 @default.
• W2766700932 creator A5069235572 @default.
• W2766700932 creator A5069496175 @default.
• W2766700932 date "2017-10-30" @default.
• W2766700932 modified "2023-09-27" @default.
• W2766700932 title "Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach" @default.
• W2766700932 cites W1968592882 @default.
• W2766700932 cites W1968645014 @default.
• W2766700932 cites W1980383541 @default.
• W2766700932 cites W1983222825 @default.
• W2766700932 cites W1983313907 @default.
• W2766700932 cites W1989210604 @default.
• W2766700932 cites W1991060266 @default.
• W2766700932 cites W1993021769 @default.
• W2766700932 cites W1994178042 @default.
• W2766700932 cites W1997824873 @default.
• W2766700932 cites W2002521887 @default.
• W2766700932 cites W2021314042 @default.
• W2766700932 cites W2024217910 @default.
• W2766700932 cites W2041415289 @default.
• W2766700932 cites W2044431281 @default.
• W2766700932 cites W2049822919 @default.
• W2766700932 cites W2052358899 @default.
• W2766700932 cites W2062000303 @default.
• W2766700932 cites W2063238746 @default.
• W2766700932 cites W2067520769 @default.
• W2766700932 cites W2067531575 @default.
• W2766700932 cites W2073934391 @default.
• W2766700932 cites W2080756964 @default.
• W2766700932 cites W2081238838 @default.
• W2766700932 cites W2089182266 @default.
• W2766700932 cites W2095359507 @default.
• W2766700932 cites W2118313706 @default.
• W2766700932 cites W2120453365 @default.
• W2766700932 cites W2126237934 @default.
• W2766700932 cites W2127058414 @default.
• W2766700932 cites W2141715168 @default.
• W2766700932 cites W2162577349 @default.
• W2766700932 cites W2163821296 @default.
• W2766700932 cites W2165463461 @default.
• W2766700932 cites W2165948908 @default.
• W2766700932 cites W2187482341 @default.
• W2766700932 cites W2415347524 @default.
• W2766700932 cites W2444067331 @default.
• W2766700932 doi "https://doi.org/10.18632/oncotarget.22149" @default.
• W2766700932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5739786" @default.
• W2766700932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29291001" @default.
• W2766700932 hasPublicationYear "2017" @default.
• W2766700932 type Work @default.
• W2766700932 sameAs 2766700932 @default.
• W2766700932 citedByCount "19" @default.
• W2766700932 countsByYear W27667009322018 @default.
• W2766700932 countsByYear W27667009322019 @default.
• W2766700932 countsByYear W27667009322020 @default.
• W2766700932 countsByYear W27667009322021 @default.
• W2766700932 countsByYear W27667009322022 @default.
• W2766700932 countsByYear W27667009322023 @default.
• W2766700932 crossrefType "journal-article" @default.
• W2766700932 hasAuthorship W2766700932A5000966873 @default.
• W2766700932 hasAuthorship W2766700932A5002090011 @default.
• W2766700932 hasAuthorship W2766700932A5010023491 @default.
• W2766700932 hasAuthorship W2766700932A5017332423 @default.
• W2766700932 hasAuthorship W2766700932A5019440060 @default.
• W2766700932 hasAuthorship W2766700932A5020301050 @default.
• W2766700932 hasAuthorship W2766700932A5022107190 @default.
• W2766700932 hasAuthorship W2766700932A5028142206 @default.
• W2766700932 hasAuthorship W2766700932A5032801385 @default.
• W2766700932 hasAuthorship W2766700932A5033687873 @default.
• W2766700932 hasAuthorship W2766700932A5034105171 @default.
• W2766700932 hasAuthorship W2766700932A5036278151 @default.
• W2766700932 hasAuthorship W2766700932A5043978744 @default.
• W2766700932 hasAuthorship W2766700932A5047261124 @default.
• W2766700932 hasAuthorship W2766700932A5055195598 @default.
• W2766700932 hasAuthorship W2766700932A5062738958 @default.
• W2766700932 hasAuthorship W2766700932A5062920022 @default.
• W2766700932 hasAuthorship W2766700932A5069235572 @default.
• W2766700932 hasAuthorship W2766700932A5069496175 @default.
• W2766700932 hasBestOaLocation W27667009321 @default.
• W2766700932 hasConcept C121608353 @default.
• W2766700932 hasConcept C126322002 @default.

• next