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- W2766702448 abstract "Back ground: Prostate-Specific membrane Antigen has been known as a tumor associated neovasculature marker in some solid malignant tumors and targeting of that by cytotoxic- conjugated antibody can represent powerful tool for vascular targeted therapy in malignant tumors. In thyroid, it appears that angiogenesis factors are involved in neoplastic growth and aggressiveness of tumors. This study was conducted to evaluate the expression of PSMA as an angiogensis factor by immunohistochemistry in neovasculature of thyroid follicular neoplasms to determine its usefulness for distinguishing between adenoma and carcinoma . Methods: Paraffin Blocks of formalin fixed samples representing 48 cases of Follicular Thyroid adenoma and 15 cases of Follicular Thyroid Carcinoma were evaluated. Results: Among Carcinomas, capsular and vascular invasion were present in 12 and 11 cases , respectively. The intensity of PSMA staining was significantly higher in carcinoma group(p=0.028). However, no significant difference in extent of PSMA expression in adenoma and carcinoma groups was observed(p=0.239).Thyroid follicular cells in adenoma, carcinoma also non neoplastic area were negative for PSMA. Conclusion: Our findings do not support usefulness of PSMA in differentiating between FTA and FTC. However ; expression in neovasculature of differentiated thyroid tumors can represent a potential utility for PSMA-targeted radionuclide therapy in advanced differentiated thyroid cancers. DOI:10.21276/APALM.1511" @default.
- W2766702448 created "2017-11-10" @default.
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- W2766702448 date "2017-10-01" @default.
- W2766702448 modified "2023-10-12" @default.
- W2766702448 title "Expression of PSMA in Thyroid follicular neoplasms: Utility for differentiating between benign from malignant lesions" @default.
- W2766702448 doi "https://doi.org/10.21276/apalm.1511" @default.
- W2766702448 hasPublicationYear "2017" @default.
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