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• W2766705036 abstract "Diabetes is a risk factor for the development of cognitive impairment and possibly for accelerated progression to Alzheimer disease (AD) and other dementias, though the trajectory of overall cognitive decline and in specific cognitive domains is unclear. Using the National Alzheimer's Coordinating Center Uniform Data Set (NACC-UDS) to identify elders 65 or older with normal cognition (N=7,663), and Mild Cognitive Impairment (MCI, N=4,114), we compared overall cognitive and domain specific scores and their progression over time between diabetics and non-diabetics. Diagnoses were determined by clinician consensus. Diabetes was based on clinician assessment of subject's medical history. Cognition was assessed using ten neuropsychological measures in four separate domains: memory, attention, language, and executive function, from which a normalized cognitive composite (CC) score was constructed. Mixed effects regressions were used to compare differences in the trajectories of CC and subdomain scores in diabetic vs non-diabetic subjects over time for each diagnosis group separately. Control variables included baseline MMSE, age, gender, race/ethnicity, education, and comorbidities. Diabetes was more common among those with MCI (14.7%) than among cognitively normal controls (11.7%). In cognitively normal group, diabetics had lower CC scores than non-diabetics at baseline and a small but significant accelerated rate of decline. In MCI groups, diabetics had lower CC scores at baseline and a small but significant slower rate of decline. At baseline, in all diagnosis groups, memory domain scores were similar between diabetics and non-diabetics but all non-memory domains were worse in diabetics. Overtime, in all diagnosis groups, performance in all non-memory domains declined in non-diabetics. In cognitively normal group, diabetics had a slightly accelerated rate of decline over time in language and executive function domains. In aMCI group, diabetics had significantly slower deterioration in attention and language domains. In naMCI group, diabetics had significantly slower deterioration in executive function domain. Diabetes may be associated with lower cognitive performance, primarily in non-memory domains. However, it is not associated with continued worsening, suggesting a static deficit with minimal memory involvement. This suggests that diabetes may contribution more to a vascular profile of cognitive impairment and not to that typical of AD." @default.
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• W2766705036 date "2017-07-01" @default.
• W2766705036 modified "2023-10-16" @default.
• W2766705036 title "[P1-502]: NON-AMNESTIC DEFICIT CHARACTERIZES THE COGNITIVE PROFILE IN DIABETES: RESULTS FROM NATIONAL ALZHEIMER'S COORDINATING CENTER'S UNIFORM DATA SET (NACC UDS)" @default.
• W2766705036 doi "https://doi.org/10.1016/j.jalz.2017.06.518" @default.
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