FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766706536> ?p ?o ?g. }

• W2766706536 abstract "Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D tumor recognition system as well as impaired signaling by other activating NK cell receptors. Several in vitro studies suggested that sustained engagement of the NKG2D receptor, as it is occurring in the tumor microenvironment, not only impairs expression and function of NKG2D but also impacts signaling by other activating NK receptors. Here, we made use of a transgenic mouse model of ubiquitous NKG2D ligand expression (H2-Kb-MICA mice) to investigate consequences of chronic NKG2D engagement in vivo for functional responsiveness by other activating NK receptors such as NKp46 and Ly49D. Unexpectedly, we found no evidence for an impairment of NKp46 expression and function in H2-Kb-MICA mice, as anticipated from previous in vitro experiments. However, we observed a marked downregulation and dysfunction of the activating receptor Ly49D in activated NK cells from H2-Kb-MICA mice. Ly49D shares the adaptor proteins DAP10 and DAP12 with NKG2D possibly explaining the collateral impairment of Ly49D function in situations of chronic NKG2D engagement. Altogether, our results demonstrate that persistent engagement of NKG2D in vivo, as often observed in tumors, can selectively impair functions of unrelated NK receptors and thereby compromise NK responsiveness to third-party antigens." @default.
• W2766706536 created "2017-11-10" @default.
• W2766706536 creator A5004327073 @default.
• W2766706536 creator A5006659812 @default.
• W2766706536 creator A5032233290 @default.
• W2766706536 creator A5043726886 @default.
• W2766706536 creator A5082018407 @default.
• W2766706536 date "2017-11-03" @default.
• W2766706536 modified "2023-10-14" @default.
• W2766706536 title "Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors" @default.
• W2766706536 cites W1969950463 @default.
• W2766706536 cites W1972494701 @default.
• W2766706536 cites W1976952965 @default.
• W2766706536 cites W1982780404 @default.
• W2766706536 cites W1985684774 @default.
• W2766706536 cites W1993786192 @default.
• W2766706536 cites W1994048709 @default.
• W2766706536 cites W1995539088 @default.
• W2766706536 cites W1996145004 @default.
• W2766706536 cites W1999341606 @default.
• W2766706536 cites W2005765588 @default.
• W2766706536 cites W2007826451 @default.
• W2766706536 cites W2010749951 @default.
• W2766706536 cites W2011017810 @default.
• W2766706536 cites W2014349052 @default.
• W2766706536 cites W2023370541 @default.
• W2766706536 cites W2026859850 @default.
• W2766706536 cites W2031757213 @default.
• W2766706536 cites W2036043979 @default.
• W2766706536 cites W2036806857 @default.
• W2766706536 cites W2036883291 @default.
• W2766706536 cites W2037057992 @default.
• W2766706536 cites W2041953257 @default.
• W2766706536 cites W2046949604 @default.
• W2766706536 cites W2053041715 @default.
• W2766706536 cites W2056204715 @default.
• W2766706536 cites W2061262594 @default.
• W2766706536 cites W2063192133 @default.
• W2766706536 cites W2064920472 @default.
• W2766706536 cites W2070154805 @default.
• W2766706536 cites W2078165683 @default.
• W2766706536 cites W2079288189 @default.
• W2766706536 cites W2092430492 @default.
• W2766706536 cites W2093851425 @default.
• W2766706536 cites W2095411789 @default.
• W2766706536 cites W2098920847 @default.
• W2766706536 cites W2103897906 @default.
• W2766706536 cites W2120372745 @default.
• W2766706536 cites W2124346622 @default.
• W2766706536 cites W2125163646 @default.
• W2766706536 cites W2125337252 @default.
• W2766706536 cites W2134824958 @default.
• W2766706536 cites W2143731593 @default.
• W2766706536 cites W2146783950 @default.
• W2766706536 cites W2150943213 @default.
• W2766706536 cites W2155344565 @default.
• W2766706536 cites W2162609785 @default.
• W2766706536 cites W2166970460 @default.
• W2766706536 cites W2170069789 @default.
• W2766706536 cites W2221432805 @default.
• W2766706536 cites W2266564746 @default.
• W2766706536 cites W2521771944 @default.
• W2766706536 cites W2572174216 @default.
• W2766706536 doi "https://doi.org/10.3389/fimmu.2017.01466" @default.
• W2766706536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5675847" @default.
• W2766706536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29163533" @default.
• W2766706536 hasPublicationYear "2017" @default.
• W2766706536 type Work @default.
• W2766706536 sameAs 2766706536 @default.
• W2766706536 citedByCount "17" @default.
• W2766706536 countsByYear W27667065362018 @default.
• W2766706536 countsByYear W27667065362019 @default.
• W2766706536 countsByYear W27667065362020 @default.
• W2766706536 countsByYear W27667065362021 @default.
• W2766706536 countsByYear W27667065362022 @default.
• W2766706536 countsByYear W27667065362023 @default.
• W2766706536 crossrefType "journal-article" @default.
• W2766706536 hasAuthorship W2766706536A5004327073 @default.
• W2766706536 hasAuthorship W2766706536A5006659812 @default.
• W2766706536 hasAuthorship W2766706536A5032233290 @default.
• W2766706536 hasAuthorship W2766706536A5043726886 @default.
• W2766706536 hasAuthorship W2766706536A5082018407 @default.
• W2766706536 hasBestOaLocation W27667065361 @default.
• W2766706536 hasConcept C104317684 @default.
• W2766706536 hasConcept C109316439 @default.
• W2766706536 hasConcept C127561419 @default.
• W2766706536 hasConcept C150903083 @default.
• W2766706536 hasConcept C170493617 @default.
• W2766706536 hasConcept C202751555 @default.
• W2766706536 hasConcept C203014093 @default.
• W2766706536 hasConcept C207001950 @default.
• W2766706536 hasConcept C2778867473 @default.
• W2766706536 hasConcept C502942594 @default.
• W2766706536 hasConcept C55493867 @default.
• W2766706536 hasConcept C86803240 @default.
• W2766706536 hasConcept C95444343 @default.
• W2766706536 hasConceptScore W2766706536C104317684 @default.
• W2766706536 hasConceptScore W2766706536C109316439 @default.
• W2766706536 hasConceptScore W2766706536C127561419 @default.
• W2766706536 hasConceptScore W2766706536C150903083 @default.

• next