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- W2766709575 abstract "An improved and greener protocol has been developed for the synthesis of 2,4‐disubstituted thiazoles via C–Br, C–S, and, C–N bond formations in a single step from readily available ketones, N ‐bromosuccinimide (NBS), and thiourea catalyzed by citric acid in a mixture of ethanol and water (3:1) under reflux conditions. This method has the advantages of freedom from the isolation of lachrymatory α‐bromoketones, ease of carrying out, cleaner reaction profile, broad substrate scope, freedom from chromatographic purification, and suitability for large‐scale synthesis." @default.
- W2766709575 created "2017-11-10" @default.
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- W2766709575 date "2017-10-16" @default.
- W2766709575 modified "2023-10-05" @default.
- W2766709575 title "Citric Acid-catalyzed Synthesis of 2,4-Disubstituted Thiazoles from Ketones via C-Br, C-S, and C-N Bond Formations in One Pot: A Green Approach" @default.
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- W2766709575 doi "https://doi.org/10.1002/jccs.201700200" @default.
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