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- W2766720118 abstract "Gold nanoparticles (AuNPs) and matrix metalloproteinase (MMP)-2 cleavable peptides are clicked into gold nanoparticle clusters (AuNCs) for enhanced drug localization and micro computerized tomography (μCT) theranostic of tumors. AuNPs are co-functionalized with doxorubicin (DOX) and an azide-terminated polymer (DOX/N3@AuNPs), and the DOX/N3@AuNPs are associated into [email protected] in the presence of an alkyne-terminated MMP-2 cleavable peptide (alkyne-peptide-alkyne; APA) by click chemistry. MMP-2-dependent dissociation shows that DOX[email protected] are highly sensitive to the MMP-2 and are almost completed digested into single nanoparticles. DOX liberation shows that > 75% of the conjugated DOX is bursted out from the digested [email protected] while < 20% of DOX is released from the integrate [email protected] within 3 h in acidic conditions, suggesting that DOX is only liberated from dissociated [email protected] in acidic conditions. In vivo study shows that [email protected] accumulate in tumor ~ 150 times higher than DOX/N3@AuNPs do and efficiently suppress tumor growth. Mice administered with AuNCs shows clearer μCT images of tumors. Thus, [email protected] are expected promising carriers for both anticancer therapy and tumor imaging." @default.
- W2766720118 created "2017-11-10" @default.
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- W2766720118 date "2018-01-01" @default.
- W2766720118 modified "2023-10-12" @default.
- W2766720118 title "Doxorubicin encapsulated clicked gold nanoparticle clusters exhibiting tumor-specific disassembly for enhanced tumor localization and computerized tomographic imaging" @default.
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- W2766720118 doi "https://doi.org/10.1016/j.jconrel.2017.11.003" @default.
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