FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766720839> ?p ?o ?g. }

• W2766720839 endingPage "18" @default.
• W2766720839 startingPage "8" @default.
• W2766720839 abstract "Toll-like receptors (TLRs) are important innate immune receptors that recognize multiple pathogen-associated molecular patterns (PAMPs) and activate the immune responses to resist the invasion of pathogens. Many TLRs need assistance from trafficking chaperones to transport to the specific cell compartments and then are processed before they are activated. In this study, we identified an important trafficking chaperone, Unc-93 homolog B1 (unc93b1), from the Epinephelus coioides (orange-spotted grouper). The deduced protein sequence of Eco.unc93b1 was 632 amino acids, containing 12 transmembrane domains, consistent with other UNC93B1 proteins from other species. Phylogenetic analysis showed that Eco.Unc93b1 was clustered with teleost Unc93b1 and had the closest relationship with Larimichthys crocea (large yellow croaker) Unc93b1. Eco.unc93b1 was expressed the highest in the spleen, and its protein was co-localized with the endoplasmic reticulum and early endosomes in both human embryonic kidney 293T cells and grouper spleen cells (GS cells). Moreover, the stimulation of lipopolysaccharide (LPS), high-molecular-weight poly (I:C) (HMW), imidazoquinoline (R848), polyadenylic-polyuridylic acid (poly AU), and 19-mer Staphylococcus aureus 23S rRNA-derived oligoribonucleotide (ORN Sa 19) promoted the mRNA expression of unc93b1 in GS cells with different patterns. Furthermore, the cytokine expression induced by these PAMPs was suppressed, while Eco.unc93b1 was knocked down, by small interfering RNA. In conclusion, these results suggest that Eco.unc93b1 plays an essential role in several PAMP-induced immune responses." @default.
• W2766720839 created "2017-11-10" @default.
• W2766720839 creator A5009726171 @default.
• W2766720839 creator A5011916006 @default.
• W2766720839 creator A5015480789 @default.
• W2766720839 creator A5018312511 @default.
• W2766720839 creator A5026412404 @default.
• W2766720839 creator A5035073435 @default.
• W2766720839 creator A5054465388 @default.
• W2766720839 creator A5064222660 @default.
• W2766720839 creator A5079594267 @default.
• W2766720839 creator A5082055855 @default.
• W2766720839 creator A5090872318 @default.
• W2766720839 date "2018-04-01" @default.
• W2766720839 modified "2023-10-15" @default.
• W2766720839 title "Unc93b1 is essential for cytokine activation of five PAMPs in the orange-spotted grouper (Epinephelus coioides)" @default.
• W2766720839 cites W1505229526 @default.
• W2766720839 cites W1592957814 @default.
• W2766720839 cites W1965342008 @default.
• W2766720839 cites W1967751929 @default.
• W2766720839 cites W1971612972 @default.
• W2766720839 cites W1973659410 @default.
• W2766720839 cites W1985029443 @default.
• W2766720839 cites W1987410025 @default.
• W2766720839 cites W1990595263 @default.
• W2766720839 cites W2001757395 @default.
• W2766720839 cites W2017267708 @default.
• W2766720839 cites W2019077744 @default.
• W2766720839 cites W2021361448 @default.
• W2766720839 cites W2035253913 @default.
• W2766720839 cites W2037071509 @default.
• W2766720839 cites W2038548285 @default.
• W2766720839 cites W2042732565 @default.
• W2766720839 cites W2055773854 @default.
• W2766720839 cites W2061203855 @default.
• W2766720839 cites W2062835892 @default.
• W2766720839 cites W2068320950 @default.
• W2766720839 cites W2074093443 @default.
• W2766720839 cites W2091817471 @default.
• W2766720839 cites W2099533280 @default.
• W2766720839 cites W2103287192 @default.
• W2766720839 cites W2109379806 @default.
• W2766720839 cites W2109491705 @default.
• W2766720839 cites W2126775275 @default.
• W2766720839 cites W2127745150 @default.
• W2766720839 cites W2142563401 @default.
• W2766720839 cites W2157979276 @default.
• W2766720839 cites W2161284816 @default.
• W2766720839 cites W2169283267 @default.
• W2766720839 cites W2171907587 @default.
• W2766720839 cites W2202212112 @default.
• W2766720839 cites W2296195665 @default.
• W2766720839 cites W2558035065 @default.
• W2766720839 cites W4296148538 @default.
• W2766720839 doi "https://doi.org/10.1016/j.dci.2017.10.018" @default.
• W2766720839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29097235" @default.
• W2766720839 hasPublicationYear "2018" @default.
• W2766720839 type Work @default.
• W2766720839 sameAs 2766720839 @default.
• W2766720839 citedByCount "5" @default.
• W2766720839 countsByYear W27667208392019 @default.
• W2766720839 countsByYear W27667208392021 @default.
• W2766720839 countsByYear W27667208392022 @default.
• W2766720839 countsByYear W27667208392023 @default.
• W2766720839 crossrefType "journal-article" @default.
• W2766720839 hasAuthorship W2766720839A5009726171 @default.
• W2766720839 hasAuthorship W2766720839A5011916006 @default.
• W2766720839 hasAuthorship W2766720839A5015480789 @default.
• W2766720839 hasAuthorship W2766720839A5018312511 @default.
• W2766720839 hasAuthorship W2766720839A5026412404 @default.
• W2766720839 hasAuthorship W2766720839A5035073435 @default.
• W2766720839 hasAuthorship W2766720839A5054465388 @default.
• W2766720839 hasAuthorship W2766720839A5064222660 @default.
• W2766720839 hasAuthorship W2766720839A5079594267 @default.
• W2766720839 hasAuthorship W2766720839A5082055855 @default.
• W2766720839 hasAuthorship W2766720839A5090872318 @default.
• W2766720839 hasConcept C136449434 @default.
• W2766720839 hasConcept C153911025 @default.
• W2766720839 hasConcept C203014093 @default.
• W2766720839 hasConcept C2776112240 @default.
• W2766720839 hasConcept C2778967481 @default.
• W2766720839 hasConcept C2780931953 @default.
• W2766720839 hasConcept C2909208804 @default.
• W2766720839 hasConcept C505870484 @default.
• W2766720839 hasConcept C86803240 @default.
• W2766720839 hasConcept C8891405 @default.
• W2766720839 hasConcept C95444343 @default.
• W2766720839 hasConceptScore W2766720839C136449434 @default.
• W2766720839 hasConceptScore W2766720839C153911025 @default.
• W2766720839 hasConceptScore W2766720839C203014093 @default.
• W2766720839 hasConceptScore W2766720839C2776112240 @default.
• W2766720839 hasConceptScore W2766720839C2778967481 @default.
• W2766720839 hasConceptScore W2766720839C2780931953 @default.
• W2766720839 hasConceptScore W2766720839C2909208804 @default.
• W2766720839 hasConceptScore W2766720839C505870484 @default.
• W2766720839 hasConceptScore W2766720839C86803240 @default.
• W2766720839 hasConceptScore W2766720839C8891405 @default.
• W2766720839 hasConceptScore W2766720839C95444343 @default.

• next