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• W2766753906 startingPage "65" @default.
• W2766753906 abstract "Recently, we reported 2 mixed endometrioid endometrial carcinomas with a low-grade serous-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 cases and added a third case. Immunoreactivity for p53, ER, Ki67, WT1, MLH1, PMS2, MSH2, and MSH6 was assessed. Targeted next-generation sequencing for somatic mutations, including genes commonly implicated in carcinogenesis including TP53, KRAS, and PIK3CA, and Sanger sequencing for PTEN and POLE were also performed. All patients were nulliparous and had morbid obesity. Their tumors showed a micropapillary component that resembled that of ovarian low-grade serous carcinoma and merged with villoglandular endometrioid carcinoma. The invasive tumor glands exhibited a microcystic, elongated, or fragmented pattern and contained psammoma bodies. Two tumors showed aberrant p53 expression, and all 3 were positive for ER. All showed KRAS mutations, and TP53 mutations were found in 2 cases. One patient developed peritoneal carcinomatosis, one patient is alive with disease, and another died of a brain tumor. The third patient, whose tumor was confined to the uterus (stage IA), is alive without evidence of disease, but she has been followed for only 6 months. Mixed endometrial carcinomas with a low-grade serous-like component exhibit a morphologic spectrum of endometrioid and serous differentiation with microcystic, elongated, or fragmented features; ER expression; KRAS and TP53 mutations; and aggressive behavior." @default.
• W2766753906 created "2017-11-10" @default.
• W2766753906 creator A5008381818 @default.
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• W2766753906 date "2018-01-01" @default.
• W2766753906 modified "2023-10-16" @default.
• W2766753906 title "Mixed endometrial carcinomas with a “low-grade serous”–like component: a clinicopathologic, immunohistochemical, and molecular genetic study" @default.
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• W2766753906 doi "https://doi.org/10.1016/j.humpath.2017.10.016" @default.
• W2766753906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29079180" @default.
• W2766753906 hasPublicationYear "2018" @default.
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