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- W2766769293 endingPage "169" @default.
- W2766769293 startingPage "143" @default.
- W2766769293 abstract "Carbon black is produced industrially by the partial combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions. It is considered a poorly soluble, low toxicity (PSLT) particle. Recently, results from a number of published studies have suggested that carbon black may be directly genotoxic, and that it may also cause reproductive toxicity. Here, we review the evidence from these studies to determine whether carbon black is likely to act as a primary genotoxicant or reproductive toxicant in humans. For the genotoxicity endpoint, the available evidence clearly shows that carbon black does not directly interact with DNA. However, the study results are consistent with the mechanism that, at high enough concentrations, carbon black causes inflammation and oxidative stress in the lung leading to mutations, which is a secondary genotoxic mechanism. For the reproductive toxicity endpoint for carbon black, to date, there are various lung instillation studies and one short-term inhalation study that evaluated a selected number of reproduction endpoints (e.g. gestational and litter parameters) as well as other general endpoints (e.g. gene expression, neurofunction, DNA damage); usually at one time point or using a single dose. It is possible that some of the adverse effects observed in these studies may be the result of non-specific inflammatory effects caused by high exposure doses. An oral gavage study reported no adverse reproductive or developmental effects at the highest dose tested. The overall weight of evidence indicates that carbon black should not be considered a direct genotoxicant or reproductive toxicant." @default.
- W2766769293 created "2017-11-10" @default.
- W2766769293 creator A5001949816 @default.
- W2766769293 creator A5017587839 @default.
- W2766769293 creator A5027893510 @default.
- W2766769293 creator A5088566213 @default.
- W2766769293 date "2017-11-02" @default.
- W2766769293 modified "2023-10-11" @default.
- W2766769293 title "Evaluating the evidence on genotoxicity and reproductive toxicity of carbon black: a critical review" @default.
- W2766769293 cites W1479972754 @default.
- W2766769293 cites W1586066921 @default.
- W2766769293 cites W1606465882 @default.
- W2766769293 cites W1832818975 @default.
- W2766769293 cites W1966079664 @default.
- W2766769293 cites W1972123783 @default.
- W2766769293 cites W1973192479 @default.
- W2766769293 cites W1975788652 @default.
- W2766769293 cites W1982488232 @default.
- W2766769293 cites W1985892272 @default.
- W2766769293 cites W1991700059 @default.
- W2766769293 cites W1996197564 @default.
- W2766769293 cites W1998267895 @default.
- W2766769293 cites W1998429989 @default.
- W2766769293 cites W2000257056 @default.
- W2766769293 cites W2001931101 @default.
- W2766769293 cites W2004668395 @default.
- W2766769293 cites W2005163676 @default.
- W2766769293 cites W2011707607 @default.
- W2766769293 cites W2012117396 @default.
- W2766769293 cites W2022337460 @default.
- W2766769293 cites W2024272741 @default.
- W2766769293 cites W2025303352 @default.
- W2766769293 cites W2026088077 @default.
- W2766769293 cites W2029454841 @default.
- W2766769293 cites W2029924301 @default.
- W2766769293 cites W2031148890 @default.
- W2766769293 cites W2031388659 @default.
- W2766769293 cites W2036350037 @default.
- W2766769293 cites W2036847201 @default.
- W2766769293 cites W2037223658 @default.
- W2766769293 cites W2037502174 @default.
- W2766769293 cites W2040558826 @default.
- W2766769293 cites W2041577840 @default.
- W2766769293 cites W2041674455 @default.
- W2766769293 cites W2042669079 @default.
- W2766769293 cites W2045359131 @default.
- W2766769293 cites W2045978507 @default.
- W2766769293 cites W2047377621 @default.
- W2766769293 cites W2049869110 @default.
- W2766769293 cites W2052947934 @default.
- W2766769293 cites W2053832484 @default.
- W2766769293 cites W2054362610 @default.
- W2766769293 cites W2061293964 @default.
- W2766769293 cites W2061783503 @default.
- W2766769293 cites W2062359569 @default.
- W2766769293 cites W2063298138 @default.
- W2766769293 cites W2063943133 @default.
- W2766769293 cites W2064191532 @default.
- W2766769293 cites W2064752400 @default.
- W2766769293 cites W2069563880 @default.
- W2766769293 cites W2070634315 @default.
- W2766769293 cites W2072131879 @default.
- W2766769293 cites W2072843401 @default.
- W2766769293 cites W2074008288 @default.
- W2766769293 cites W2075728414 @default.
- W2766769293 cites W2077699069 @default.
- W2766769293 cites W2078420680 @default.
- W2766769293 cites W2080077779 @default.
- W2766769293 cites W2082512011 @default.
- W2766769293 cites W2083700258 @default.
- W2766769293 cites W2085679753 @default.
- W2766769293 cites W2086684376 @default.
- W2766769293 cites W2099868663 @default.
- W2766769293 cites W2101245680 @default.
- W2766769293 cites W2101825576 @default.
- W2766769293 cites W2107405091 @default.
- W2766769293 cites W2113634951 @default.
- W2766769293 cites W2115847418 @default.
- W2766769293 cites W2115993724 @default.
- W2766769293 cites W2118642429 @default.
- W2766769293 cites W2120166044 @default.
- W2766769293 cites W2122889851 @default.
- W2766769293 cites W2123745142 @default.
- W2766769293 cites W2124170215 @default.
- W2766769293 cites W2124717298 @default.
- W2766769293 cites W2130292493 @default.
- W2766769293 cites W2132286254 @default.
- W2766769293 cites W2133145334 @default.
- W2766769293 cites W2133342524 @default.
- W2766769293 cites W2133817540 @default.
- W2766769293 cites W2137098239 @default.
- W2766769293 cites W2141864709 @default.
- W2766769293 cites W2145352831 @default.
- W2766769293 cites W2145465393 @default.
- W2766769293 cites W2150500173 @default.
- W2766769293 cites W2153231621 @default.
- W2766769293 cites W2153452079 @default.
- W2766769293 cites W2155687923 @default.