Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766772553> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2766772553 abstract "The adoptive transfer of viral-specific T-cells (VSTs) is highly effective in treating viral infections after allogeneic hematopoietic stem cell transplant. Unfortunately, adoptive T-cell therapy is not available for a large number of patients due to logistical constraints associated with isolating and manufacturing enough VSTs from healthy donors. We have shown that a single exercise bout reliably augments the ex vivoexpansion of VSTs and thus might be useful as a clinical adjuvant to boost the manufacture of VSTs from healthy donors. We sought to determine if the augmenting effects of exercise on VST expansion are dependent on β2 adrenergic receptor (β2AR) signaling. Using a randomized cross-over and double-blinded design, ten subjects performed 30-min of steady state cycling exercise 3 h after ingesting (i) a placebo, (ii) a β1 + 2AR antagonist (nadolol), or (iii) a β1AR antagonist (bisoprolol). PBMCs isolated before and after exercise were stimulated with Adenovirus (AdV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) peptide antigens and cultured for 8 days, after which VSTs were enumerated by IFNγ ELISPOT. Compared to resting conditions, exercise augmented the expansion of VSTs in the placebo and bisoprolol trials (38.2% and 57.9% increases), but not in the nadolol trial (3.3% decrease). We conclude that the augmenting effects of exercise on VST expansion are dependent on β2AR signaling, highlighting the β2AR as a potential target to increase the potency of T-cell therapeutics." @default.
- W2766772553 created "2017-11-10" @default.
- W2766772553 creator A5000352822 @default.
- W2766772553 creator A5006134549 @default.
- W2766772553 creator A5013300776 @default.
- W2766772553 creator A5020122230 @default.
- W2766772553 creator A5021637559 @default.
- W2766772553 creator A5049242633 @default.
- W2766772553 creator A5049630969 @default.
- W2766772553 creator A5050739987 @default.
- W2766772553 creator A5060283020 @default.
- W2766772553 creator A5061463253 @default.
- W2766772553 creator A5078327229 @default.
- W2766772553 date "2017-11-01" @default.
- W2766772553 modified "2023-10-18" @default.
- W2766772553 title "Exercise augments the ex vivo expansion of viral-specific T-cells for adoptive transfer immunotherapy via β 2-adrenergic receptor signaling" @default.
- W2766772553 doi "https://doi.org/10.1016/j.bbi.2017.07.063" @default.
- W2766772553 hasPublicationYear "2017" @default.
- W2766772553 type Work @default.
- W2766772553 sameAs 2766772553 @default.
- W2766772553 citedByCount "0" @default.
- W2766772553 crossrefType "journal-article" @default.
- W2766772553 hasAuthorship W2766772553A5000352822 @default.
- W2766772553 hasAuthorship W2766772553A5006134549 @default.
- W2766772553 hasAuthorship W2766772553A5013300776 @default.
- W2766772553 hasAuthorship W2766772553A5020122230 @default.
- W2766772553 hasAuthorship W2766772553A5021637559 @default.
- W2766772553 hasAuthorship W2766772553A5049242633 @default.
- W2766772553 hasAuthorship W2766772553A5049630969 @default.
- W2766772553 hasAuthorship W2766772553A5050739987 @default.
- W2766772553 hasAuthorship W2766772553A5060283020 @default.
- W2766772553 hasAuthorship W2766772553A5061463253 @default.
- W2766772553 hasAuthorship W2766772553A5078327229 @default.
- W2766772553 hasConcept C126322002 @default.
- W2766772553 hasConcept C150903083 @default.
- W2766772553 hasConcept C203014093 @default.
- W2766772553 hasConcept C207001950 @default.
- W2766772553 hasConcept C26291073 @default.
- W2766772553 hasConcept C2776090121 @default.
- W2766772553 hasConcept C2776256041 @default.
- W2766772553 hasConcept C2778151854 @default.
- W2766772553 hasConcept C71924100 @default.
- W2766772553 hasConcept C86803240 @default.
- W2766772553 hasConcept C8891405 @default.
- W2766772553 hasConcept C90375314 @default.
- W2766772553 hasConcept C98274493 @default.
- W2766772553 hasConceptScore W2766772553C126322002 @default.
- W2766772553 hasConceptScore W2766772553C150903083 @default.
- W2766772553 hasConceptScore W2766772553C203014093 @default.
- W2766772553 hasConceptScore W2766772553C207001950 @default.
- W2766772553 hasConceptScore W2766772553C26291073 @default.
- W2766772553 hasConceptScore W2766772553C2776090121 @default.
- W2766772553 hasConceptScore W2766772553C2776256041 @default.
- W2766772553 hasConceptScore W2766772553C2778151854 @default.
- W2766772553 hasConceptScore W2766772553C71924100 @default.
- W2766772553 hasConceptScore W2766772553C86803240 @default.
- W2766772553 hasConceptScore W2766772553C8891405 @default.
- W2766772553 hasConceptScore W2766772553C90375314 @default.
- W2766772553 hasConceptScore W2766772553C98274493 @default.
- W2766772553 hasLocation W27667725531 @default.
- W2766772553 hasOpenAccess W2766772553 @default.
- W2766772553 hasPrimaryLocation W27667725531 @default.
- W2766772553 hasRelatedWork W1559670159 @default.
- W2766772553 hasRelatedWork W178672938 @default.
- W2766772553 hasRelatedWork W1949560162 @default.
- W2766772553 hasRelatedWork W1974105388 @default.
- W2766772553 hasRelatedWork W2035447442 @default.
- W2766772553 hasRelatedWork W2406728158 @default.
- W2766772553 hasRelatedWork W2526159855 @default.
- W2766772553 hasRelatedWork W252770719 @default.
- W2766772553 hasRelatedWork W2564469952 @default.
- W2766772553 hasRelatedWork W2572663346 @default.
- W2766772553 hasRelatedWork W2577904657 @default.
- W2766772553 hasRelatedWork W2589922186 @default.
- W2766772553 hasRelatedWork W2606455389 @default.
- W2766772553 hasRelatedWork W2765958229 @default.
- W2766772553 hasRelatedWork W2801188103 @default.
- W2766772553 hasRelatedWork W2962188772 @default.
- W2766772553 hasRelatedWork W3018802486 @default.
- W2766772553 hasRelatedWork W3048610886 @default.
- W2766772553 hasRelatedWork W3131103739 @default.
- W2766772553 hasRelatedWork W3213463773 @default.
- W2766772553 isParatext "false" @default.
- W2766772553 isRetracted "false" @default.
- W2766772553 magId "2766772553" @default.
- W2766772553 workType "article" @default.