Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766773487> ?p ?o ?g. }
- W2766773487 endingPage "1172" @default.
- W2766773487 startingPage "1172" @default.
- W2766773487 abstract "The chemopreventive and anticancer effects of resveratrol (RSV) are widely reported in the literature. Specifically, mechanisms involving epigenetic regulation are promising targets to regulate tumor development. Bromodomains act as epigenetic readers by recognizing lysine acetylation on histone tails and boosting gene expression in order to regulate tissue-specific transcription. In this work, we showed that RSV is a pan-BET inhibitor. Using Differential Scanning Fluorimetry (DSF), we showed that RSV at 100 µM increased the melting temperature (∆Tm) of BET bromodomains by around 2.0 °C. The micromolar dissociation constant (Kd) range was characterized using Isothermal Titration Calorimetry (ITC). The RSV Kd value accounted to 6.6 µM in case of BRD4(1). Molecular docking proposed the binding mode of RSV against BRD4(1) mimicking the acetyl-lysine interactions. All these results suggest that RSV can also recognize epigenetic readers domains by interacting with BET bromodomains." @default.
- W2766773487 created "2017-11-10" @default.
- W2766773487 creator A5017132592 @default.
- W2766773487 creator A5019090807 @default.
- W2766773487 creator A5039429969 @default.
- W2766773487 creator A5047339276 @default.
- W2766773487 creator A5049883995 @default.
- W2766773487 creator A5056648248 @default.
- W2766773487 date "2017-10-27" @default.
- W2766773487 modified "2023-10-18" @default.
- W2766773487 title "Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor" @default.
- W2766773487 cites W1777548141 @default.
- W2766773487 cites W1963819309 @default.
- W2766773487 cites W1968076212 @default.
- W2766773487 cites W1985588649 @default.
- W2766773487 cites W2003872705 @default.
- W2766773487 cites W2018289835 @default.
- W2766773487 cites W2024469844 @default.
- W2766773487 cites W2027423337 @default.
- W2766773487 cites W2036755369 @default.
- W2766773487 cites W2041535798 @default.
- W2766773487 cites W2042889901 @default.
- W2766773487 cites W2063887542 @default.
- W2766773487 cites W2100837269 @default.
- W2766773487 cites W2167841611 @default.
- W2766773487 cites W2238268214 @default.
- W2766773487 cites W2297701691 @default.
- W2766773487 cites W2316698545 @default.
- W2766773487 cites W2320653071 @default.
- W2766773487 cites W2335835207 @default.
- W2766773487 cites W2346516602 @default.
- W2766773487 cites W2503456027 @default.
- W2766773487 cites W2554214884 @default.
- W2766773487 cites W2587935821 @default.
- W2766773487 cites W2604370501 @default.
- W2766773487 cites W2614434863 @default.
- W2766773487 cites W2619382034 @default.
- W2766773487 cites W2626046448 @default.
- W2766773487 doi "https://doi.org/10.3390/nu9111172" @default.
- W2766773487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5707644" @default.
- W2766773487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29077030" @default.
- W2766773487 hasPublicationYear "2017" @default.
- W2766773487 type Work @default.
- W2766773487 sameAs 2766773487 @default.
- W2766773487 citedByCount "14" @default.
- W2766773487 countsByYear W27667734872019 @default.
- W2766773487 countsByYear W27667734872020 @default.
- W2766773487 countsByYear W27667734872021 @default.
- W2766773487 countsByYear W27667734872022 @default.
- W2766773487 crossrefType "journal-article" @default.
- W2766773487 hasAuthorship W2766773487A5017132592 @default.
- W2766773487 hasAuthorship W2766773487A5019090807 @default.
- W2766773487 hasAuthorship W2766773487A5039429969 @default.
- W2766773487 hasAuthorship W2766773487A5047339276 @default.
- W2766773487 hasAuthorship W2766773487A5049883995 @default.
- W2766773487 hasAuthorship W2766773487A5056648248 @default.
- W2766773487 hasBestOaLocation W27667734871 @default.
- W2766773487 hasConcept C104317684 @default.
- W2766773487 hasConcept C107824862 @default.
- W2766773487 hasConcept C119157956 @default.
- W2766773487 hasConcept C153911025 @default.
- W2766773487 hasConcept C156911925 @default.
- W2766773487 hasConcept C170493617 @default.
- W2766773487 hasConcept C185592680 @default.
- W2766773487 hasConcept C2776816829 @default.
- W2766773487 hasConcept C2779634854 @default.
- W2766773487 hasConcept C41091548 @default.
- W2766773487 hasConcept C55493867 @default.
- W2766773487 hasConcept C64927066 @default.
- W2766773487 hasConcept C74401373 @default.
- W2766773487 hasConcept C74998103 @default.
- W2766773487 hasConcept C86803240 @default.
- W2766773487 hasConceptScore W2766773487C104317684 @default.
- W2766773487 hasConceptScore W2766773487C107824862 @default.
- W2766773487 hasConceptScore W2766773487C119157956 @default.
- W2766773487 hasConceptScore W2766773487C153911025 @default.
- W2766773487 hasConceptScore W2766773487C156911925 @default.
- W2766773487 hasConceptScore W2766773487C170493617 @default.
- W2766773487 hasConceptScore W2766773487C185592680 @default.
- W2766773487 hasConceptScore W2766773487C2776816829 @default.
- W2766773487 hasConceptScore W2766773487C2779634854 @default.
- W2766773487 hasConceptScore W2766773487C41091548 @default.
- W2766773487 hasConceptScore W2766773487C55493867 @default.
- W2766773487 hasConceptScore W2766773487C64927066 @default.
- W2766773487 hasConceptScore W2766773487C74401373 @default.
- W2766773487 hasConceptScore W2766773487C74998103 @default.
- W2766773487 hasConceptScore W2766773487C86803240 @default.
- W2766773487 hasIssue "11" @default.
- W2766773487 hasLocation W27667734871 @default.
- W2766773487 hasLocation W27667734872 @default.
- W2766773487 hasLocation W27667734873 @default.
- W2766773487 hasLocation W27667734874 @default.
- W2766773487 hasLocation W27667734875 @default.
- W2766773487 hasLocation W27667734876 @default.
- W2766773487 hasLocation W27667734877 @default.
- W2766773487 hasOpenAccess W2766773487 @default.
- W2766773487 hasPrimaryLocation W27667734871 @default.
- W2766773487 hasRelatedWork W2041652616 @default.