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• W2766788087 abstract "// Yifan Zou 1, 3, * , Jianfa Li 1, 5, * , Yincong Chen 3, * , Huizhong Xiao 1 , Fuyou Zhang 1 , Dan Yu 2, * , Kewang Luo 1, 4 1 Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China 2 Longgang District Central Hospital of Shenzhen, Shenzhen, China 3 Shantou University Medical College, Shantou, China 4 People’s Hospital of Longhua, Shenzhen, China 5 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China * These authors have contributed equally to this work Correspondence to: Dan Yu, email: 23744801@qq.com Kewang Luo, email: kewangluo@126.com Keywords: lncRNA; BANCR; diagnostic biomarker; therapeutic target Received: July 02, 2017      Accepted: September 21, 2017      Published: October 24, 2017 ABSTRACT Long non-coding RNAs account for large proportion of non-coding transcripts in human genomes. Though they lack of open reading framework and cannot encode protein, they can control endogenous gene expression though regulating cell life activities. They serve as transcriptional modulator, posttranscriptional processor, chromatin remodeler and splicing regulator during the process of gene modification. Moreover, long non-coding RNAs were regarded as potential tumor markers for cancer diagnosis and prognosis. BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Since then, increasing studies about BANCR in cancer progression were reported. BANCR was dysregulated in various cancers including melanoma, colorectal cancer, retinoblastoma, lung carcinoma and hepatocellular carcinoma, and increased BANCR expression cause poor prognosis and shorter survival rate of cancer patients. Furthermore, the functions and mechanisms of BANCR in cancer cells have been clarified. Here, we focus on the current research on the role of BANCR in the clinical management, progression and molecular mechanisms in human cancer." @default.
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• W2766788087 date "2017-10-24" @default.
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• W2766788087 title "BANCR: a novel oncogenic long non-coding RNA in human cancers" @default.
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• W2766788087 doi "https://doi.org/10.18632/oncotarget.22031" @default.
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