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- W2766789602 abstract "Posterior cingulate region's involvement in Alzheimer's disease (AD) pathogenesis has brought back the focus to Papez circuit (PC) which could have significant implications for AD's biomarker research. In addition to grey-matter regions, PC's integrity is also dependent on white matter (WM) tracts connecting those regions. Delineating the microstructural changes within WM tracts of PC during preclinical and clinical stages of AD may improve our understanding of temporal dynamics during the course of AD and ability to predict future disease. Diffusion tensor imaging (DTI) estimated fractional anisotropy (FA) in the diffusion of water through brain tissue can be used to quantify white matter micro-structural integrity. In this exploratory study, we included 45 patients with AD, 98 patients with mild cognitive impairment (MCI) and 75 cognitively normal (CN) controls. Statistical significant difference in FA between groups as determined by one-way ANCOVA after controlling for covariates including age. Between groups, significant differences in FA was observed in following regions: fornix, left (F(2,213)=14.399, p=.000) and right (F(2,213)=12.897, p=.000); stria terminalis, left (F(2,213)=15.989, p=.000) and right (F(2,213)=8.823, p=.000); cingulum (hippocampus), left (F(2,213)=6.074, p=.003) and right (F(2,213)=5.989, p=.003); cingulum, right (F(2,213)=3.315, p=.038); and, anterior corona radiata, left (F(2,213)=5.133, p=.007) and right (F(2,213)=3.397, p=.035). In pairwise comparisons after Bonferroni correction, patients with MCI showed significant FA reduction in fornix and stria terminalis, bilaterally than CN group. Patients with AD were associated with significant reduction in FA in fornix, stria terminalis, anterior corona radiate, right cingulum and right cingulum (hippocampus) compared to MCI patients. In comparison to CN, there was a widespread reduction of FA within PC in the AD group. To conclude, the disruption of WM integrity in MCI is limited to fornix and stria terminalis which connect medial temporal lobe structures (hippocampus and amygdala) to other PC structures. In AD, this disintegration is widespread within PC, also involving WM tracts also projecting to thalamic and cingulate regions. This pattern of WM alteration point towards systematic progression of AD pathology involving PC structures during the course of AD. The extent of involvement of PC can therefore be a marker of disease progression or therapeutic response." @default.
- W2766789602 created "2017-11-10" @default.
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- W2766789602 date "2017-07-01" @default.
- W2766789602 modified "2023-09-27" @default.
- W2766789602 title "[P4-256]: STRUCTURAL INTEGRITY OF WHITE MATTER TRACTS IN PAPEZ CIRCUIT DURING THE COURSE OF ALZHEIMER's DISEASE" @default.
- W2766789602 doi "https://doi.org/10.1016/j.jalz.2017.06.2125" @default.
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