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- W2766802016 abstract "Significance Mutations in the gene encoding XLαs and Gsα ( GNAS ) cause several genetic diseases and various tumors. Although alterations in XLαs activity/levels are implicated in some of these disorders, cellular actions of XLαs have remained poorly defined. We identified dynamins and sorting nexin-9, key components of clathrin-mediated endocytosis, as binding partners of XLαs and showed that XLαs, but not Gsα, restricts clathrin-mediated endocytosis and plays a role in iron/transferrin uptake in vivo. Thus, impaired or enhanced endocytosis may be involved in the pathogenesis of some of the GNAS -related diseases. Our findings also provide insights into the roles of heterotrimeric G proteins and the mechanisms underlying endocytosis, a fundamental cellular process required for nutrient uptake and regulation of cell signaling." @default.
- W2766802016 created "2017-11-10" @default.
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- W2766802016 date "2017-10-23" @default.
- W2766802016 modified "2023-09-28" @default.
- W2766802016 title "Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo" @default.
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- W2766802016 doi "https://doi.org/10.1073/pnas.1712670114" @default.
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