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• W2766807715 startingPage "129" @default.
• W2766807715 abstract "Congenital insensitivity to pain (CIP) is a rare syndrome with various clinical expressions, characterized by a dramatic impairment of pain perception since birth. In the 1980s, progress in nerve histopathology allowed to demonstrate that CIP was almost always a manifestation of hereditary sensory and autonomic neuropathies (HSAN) involving the small-calibre (A-delta and C) nerve fibres which normally transmit nociceptive inputs along sensory nerves. Identification of the genetic basis of several clinical subtypes has led to a better understanding of the mechanisms involved, emphasizing in particular the crucial role of nerve growth factor (NGF) in the development and survival of nociceptors. Recently, mutations of the gene coding for the sodium channel Nav1.7--a voltage-dependent sodium channel expressed preferentially on peripheral nociceptors and sympathetic ganglia--have been found to be the cause of CIP in patients showing a normal nerve biopsy. This radical impairment of nociception mirrors the hereditary pain syndromes associated with gain of function mutations of the same ion channel, such as familial erythromelalgia and paroxysmal extreme pain disorder. Future research with CIP patients may identify other proteins specifically involved in nociception, which might represent potential targets for chronic pain treatment. Moreover, this rare clinical syndrome offers the opportunity to address interesting neuropsychological issues, such as the role of pain experience in the construction of body image and in the empathic representation of others' pain." @default.
• W2766807715 created "2017-11-10" @default.
• W2766807715 creator A5033991909 @default.
• W2766807715 creator A5083941331 @default.
• W2766807715 date "2009-02-01" @default.
• W2766807715 modified "2023-10-06" @default.
• W2766807715 title "L’insensibilité congénitale à la douleur" @default.
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• W2766807715 doi "https://doi.org/10.1016/j.neurol.2008.05.003" @default.
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• W2766807715 hasPublicationYear "2009" @default.
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