Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766830585> ?p ?o ?g. }
- W2766830585 endingPage "210" @default.
- W2766830585 startingPage "205" @default.
- W2766830585 abstract "Cellular senescence and matrix metalloproteinases (MMPs) play an important role in liver diseases. The source and regulating factors of MMPs in senescent hepatocytes are not known. We investigated whether senescent hepatocytes secreted MMPs and if this was regulated by nuclear factor (NF)-κB.The TGF-α transgenic mouse hepatocyte line AML12 was treated with H2O2 to induce senescence. NF-κB signaling was examined by Western blotting and luciferase reporter assays. Quantitative reverse transcription polymerase chain reaction was used to evaluated expression of MMP-2, -9 and -13.AML12 cells treated with H2O2 showed the characteristic morphology of senescence. The activity of NF-κB and expression of MMP-2, -9 and -13 were increased in senescent AML12 cells. The NF-κB inhibitor BAY 11-7082 decreased the levels of MMPs.These results suggest that senescent hepatocytes are involved in the pathology of liver diseases through remodeling the extracellular matrix." @default.
- W2766830585 created "2017-11-10" @default.
- W2766830585 creator A5002563387 @default.
- W2766830585 creator A5021649875 @default.
- W2766830585 creator A5037621061 @default.
- W2766830585 creator A5040469723 @default.
- W2766830585 creator A5054948977 @default.
- W2766830585 creator A5065621415 @default.
- W2766830585 date "2017-12-01" @default.
- W2766830585 modified "2023-10-16" @default.
- W2766830585 title "Senescent hepatocyte secretion of matrix metalloproteinases is regulated by nuclear factor-κB signaling" @default.
- W2766830585 cites W1879194923 @default.
- W2766830585 cites W1910950086 @default.
- W2766830585 cites W1974144714 @default.
- W2766830585 cites W1977970646 @default.
- W2766830585 cites W1978174791 @default.
- W2766830585 cites W1996470451 @default.
- W2766830585 cites W1997020544 @default.
- W2766830585 cites W1997457418 @default.
- W2766830585 cites W2001720505 @default.
- W2766830585 cites W2002242855 @default.
- W2766830585 cites W2004314923 @default.
- W2766830585 cites W2015849020 @default.
- W2766830585 cites W2016802652 @default.
- W2766830585 cites W2025751643 @default.
- W2766830585 cites W2026914673 @default.
- W2766830585 cites W203746906 @default.
- W2766830585 cites W2038203832 @default.
- W2766830585 cites W2042140414 @default.
- W2766830585 cites W2077450385 @default.
- W2766830585 cites W2080393351 @default.
- W2766830585 cites W2083068177 @default.
- W2766830585 cites W2085197755 @default.
- W2766830585 cites W2093560519 @default.
- W2766830585 cites W2094304665 @default.
- W2766830585 cites W2104551096 @default.
- W2766830585 cites W2116054786 @default.
- W2766830585 cites W2116437342 @default.
- W2766830585 cites W2120167107 @default.
- W2766830585 cites W2179650400 @default.
- W2766830585 cites W2240063018 @default.
- W2766830585 cites W2318767358 @default.
- W2766830585 cites W2322152064 @default.
- W2766830585 cites W2419809019 @default.
- W2766830585 cites W2518194013 @default.
- W2766830585 cites W2527890107 @default.
- W2766830585 cites W4229864839 @default.
- W2766830585 doi "https://doi.org/10.1016/j.lfs.2017.10.023" @default.
- W2766830585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29054454" @default.
- W2766830585 hasPublicationYear "2017" @default.
- W2766830585 type Work @default.
- W2766830585 sameAs 2766830585 @default.
- W2766830585 citedByCount "5" @default.
- W2766830585 countsByYear W27668305852019 @default.
- W2766830585 countsByYear W27668305852022 @default.
- W2766830585 countsByYear W27668305852023 @default.
- W2766830585 crossrefType "journal-article" @default.
- W2766830585 hasAuthorship W2766830585A5002563387 @default.
- W2766830585 hasAuthorship W2766830585A5021649875 @default.
- W2766830585 hasAuthorship W2766830585A5037621061 @default.
- W2766830585 hasAuthorship W2766830585A5040469723 @default.
- W2766830585 hasAuthorship W2766830585A5054948977 @default.
- W2766830585 hasAuthorship W2766830585A5065621415 @default.
- W2766830585 hasConcept C104317684 @default.
- W2766830585 hasConcept C109523444 @default.
- W2766830585 hasConcept C134018914 @default.
- W2766830585 hasConcept C170493617 @default.
- W2766830585 hasConcept C185592680 @default.
- W2766830585 hasConcept C189165786 @default.
- W2766830585 hasConcept C202751555 @default.
- W2766830585 hasConcept C2776200302 @default.
- W2766830585 hasConcept C2776996007 @default.
- W2766830585 hasConcept C49039625 @default.
- W2766830585 hasConcept C522857546 @default.
- W2766830585 hasConcept C55493867 @default.
- W2766830585 hasConcept C62478195 @default.
- W2766830585 hasConcept C85265743 @default.
- W2766830585 hasConcept C86339819 @default.
- W2766830585 hasConcept C86803240 @default.
- W2766830585 hasConcept C95444343 @default.
- W2766830585 hasConceptScore W2766830585C104317684 @default.
- W2766830585 hasConceptScore W2766830585C109523444 @default.
- W2766830585 hasConceptScore W2766830585C134018914 @default.
- W2766830585 hasConceptScore W2766830585C170493617 @default.
- W2766830585 hasConceptScore W2766830585C185592680 @default.
- W2766830585 hasConceptScore W2766830585C189165786 @default.
- W2766830585 hasConceptScore W2766830585C202751555 @default.
- W2766830585 hasConceptScore W2766830585C2776200302 @default.
- W2766830585 hasConceptScore W2766830585C2776996007 @default.
- W2766830585 hasConceptScore W2766830585C49039625 @default.
- W2766830585 hasConceptScore W2766830585C522857546 @default.
- W2766830585 hasConceptScore W2766830585C55493867 @default.
- W2766830585 hasConceptScore W2766830585C62478195 @default.
- W2766830585 hasConceptScore W2766830585C85265743 @default.
- W2766830585 hasConceptScore W2766830585C86339819 @default.
- W2766830585 hasConceptScore W2766830585C86803240 @default.
- W2766830585 hasConceptScore W2766830585C95444343 @default.
- W2766830585 hasFunder F4320327078 @default.