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- W2766862628 abstract "Degeneration of central neurons and fibers has been observed in postmortem brains of heroin dependent patients. However, there is lack of biomarkers to predict the severity of neurodegeneration. Inflammatory C-C motif chemokine ligand 11 (CCL11, or eotaxin-1) has been reported as a potential biomarker related to neurodegeneration, including Alzheimer's disease. In this study, 344 Taiwanese heroin dependent patients under methadone maintenance treatment (MMT) were included. Levels of plasma CCL11, fibroblast growth factor 2 (FGF-2), C-C motif chemokine ligand 22 (CCL22), and C-C motif chemokine ligand 2 (CCL2) were measured by cytokine/chemokine magnetic bead panel-immunology multiplex assay, and plasma levels of amyloid beta (Aß) 40 and 42 were measured by enzyme-linked immunosorbent assay (ELISA). A functional CCL11 single nucleotide polymorphism (SNP) rs1129844 (Ala23Thr) was also genotyped from genomic DNAs. Using receiver operating characteristics curve analyses, CCL11 showed the strongest sensitivity and specificity in correlation with age by a cut-off at 45 years (AUC=0.69, P<0.0001). Patients of 45 years old or older had a significant higher plasma nicotine metabolite cotinine level, addiction duration, plasma CCL11 and FGF-2 levels. Plasma CCL11 was correlated with plasma FGF-2 level (partial r2=0.24, P<0.0001). Mutant carriers with allele of rs1129844 had a higher plasma level of Aß42, ratio of Aß42/ Aß40, and insomnia side effect symptom score than the GG genotype carriers in urine morphine test negative patients. The results provide novel information for possible mechanisms involving neurotoxicity in heroin dependent patients." @default.
- W2766862628 created "2017-11-10" @default.
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- W2766862628 date "2017-07-01" @default.
- W2766862628 modified "2023-09-26" @default.
- W2766862628 title "[P4-355]: NEURODEGENERATION BIOMARKER EOTAXIN-1 ELEVATED AT EARLY AGE IN HEROIN-DEPENDENT PATIENTS" @default.
- W2766862628 doi "https://doi.org/10.1016/j.jalz.2017.06.2226" @default.
- W2766862628 hasPublicationYear "2017" @default.
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