Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766869345> ?p ?o ?g. }
- W2766869345 endingPage "105195" @default.
- W2766869345 startingPage "105184" @default.
- W2766869345 abstract "Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution quantified by computed tomography (CT), in relation to tumor characteristics and outcome. 227 EC patients with preoperative abdominal CT scans were included. Total abdominal fat volume (TAV), subcutaneous abdominal fat volume (SAV) and visceral abdominal fat volume (VAV) were quantified, and visceral fat percentage calculated (VAV%=[VAV/TAV]x100). Waist circumference (WC) and liver density (LD) were measured, and body mass index (BMI) calculated. Data for estrogen, progesterone and androgen receptor (ERα/PR/AR) expression by immunohistochemistry were available for 149 tumors, and global gene expression data for 105 tumors. High BMI, TAV, SAV, VAV and WC, and low LD, were associated with low grade endometrioid tumors and PR and AR positivity (all p≤0.03). High VAV% was associated with high age (p<0.001), aneuploidy (p=0.01) and independently predicted reduced disease-specific survival (HR 1.05, 95% CI 1.00-1.11, p=0.041). Tumors from patients with low VAV% showed enrichment of gene sets related to immune activation and inflammation. In conclusion, high VAV% independently predicts reduced EC survival. Tumors arising in patients with low VAV% show enrichment of immune and inflammation related gene sets, suggesting that the global metabolic setting may be important for tumor immune response." @default.
- W2766869345 created "2017-11-10" @default.
- W2766869345 creator A5024780911 @default.
- W2766869345 creator A5032174631 @default.
- W2766869345 creator A5035785989 @default.
- W2766869345 creator A5045128636 @default.
- W2766869345 creator A5046533177 @default.
- W2766869345 creator A5049107000 @default.
- W2766869345 creator A5050805378 @default.
- W2766869345 creator A5050930264 @default.
- W2766869345 creator A5051745771 @default.
- W2766869345 creator A5074988967 @default.
- W2766869345 creator A5077492791 @default.
- W2766869345 creator A5082484204 @default.
- W2766869345 creator A5086936206 @default.
- W2766869345 date "2017-10-19" @default.
- W2766869345 modified "2023-09-24" @default.
- W2766869345 title "High visceral fat percentage is associated with poor outcome in endometrial cancer" @default.
- W2766869345 cites W114586477 @default.
- W2766869345 cites W1685808974 @default.
- W2766869345 cites W1912839783 @default.
- W2766869345 cites W1931932882 @default.
- W2766869345 cites W1969308141 @default.
- W2766869345 cites W1977118015 @default.
- W2766869345 cites W1978281808 @default.
- W2766869345 cites W1978583076 @default.
- W2766869345 cites W1978794638 @default.
- W2766869345 cites W1979711812 @default.
- W2766869345 cites W1982322333 @default.
- W2766869345 cites W1990760157 @default.
- W2766869345 cites W2023793158 @default.
- W2766869345 cites W2027578770 @default.
- W2766869345 cites W2031222466 @default.
- W2766869345 cites W2034825007 @default.
- W2766869345 cites W2038286008 @default.
- W2766869345 cites W2042845922 @default.
- W2766869345 cites W2043616061 @default.
- W2766869345 cites W2044446449 @default.
- W2766869345 cites W2046823649 @default.
- W2766869345 cites W2055604801 @default.
- W2766869345 cites W2056501772 @default.
- W2766869345 cites W2058987200 @default.
- W2766869345 cites W2059273277 @default.
- W2766869345 cites W2068629674 @default.
- W2766869345 cites W2076645058 @default.
- W2766869345 cites W2084877768 @default.
- W2766869345 cites W2084922607 @default.
- W2766869345 cites W2088851983 @default.
- W2766869345 cites W2097409147 @default.
- W2766869345 cites W2099540110 @default.
- W2766869345 cites W2108881204 @default.
- W2766869345 cites W2109870736 @default.
- W2766869345 cites W2117571685 @default.
- W2766869345 cites W2126944598 @default.
- W2766869345 cites W2129092296 @default.
- W2766869345 cites W2130410032 @default.
- W2766869345 cites W2154077842 @default.
- W2766869345 cites W2155226662 @default.
- W2766869345 cites W2205171299 @default.
- W2766869345 cites W2264343275 @default.
- W2766869345 cites W2283665483 @default.
- W2766869345 cites W2292714095 @default.
- W2766869345 cites W2293938031 @default.
- W2766869345 cites W2334798192 @default.
- W2766869345 cites W2465663488 @default.
- W2766869345 cites W2510411424 @default.
- W2766869345 cites W4211047904 @default.
- W2766869345 doi "https://doi.org/10.18632/oncotarget.21917" @default.
- W2766869345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5739630" @default.
- W2766869345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29285243" @default.
- W2766869345 hasPublicationYear "2017" @default.
- W2766869345 type Work @default.
- W2766869345 sameAs 2766869345 @default.
- W2766869345 citedByCount "30" @default.
- W2766869345 countsByYear W27668693452018 @default.
- W2766869345 countsByYear W27668693452019 @default.
- W2766869345 countsByYear W27668693452020 @default.
- W2766869345 countsByYear W27668693452021 @default.
- W2766869345 countsByYear W27668693452022 @default.
- W2766869345 countsByYear W27668693452023 @default.
- W2766869345 crossrefType "journal-article" @default.
- W2766869345 hasAuthorship W2766869345A5024780911 @default.
- W2766869345 hasAuthorship W2766869345A5032174631 @default.
- W2766869345 hasAuthorship W2766869345A5035785989 @default.
- W2766869345 hasAuthorship W2766869345A5045128636 @default.
- W2766869345 hasAuthorship W2766869345A5046533177 @default.
- W2766869345 hasAuthorship W2766869345A5049107000 @default.
- W2766869345 hasAuthorship W2766869345A5050805378 @default.
- W2766869345 hasAuthorship W2766869345A5050930264 @default.
- W2766869345 hasAuthorship W2766869345A5051745771 @default.
- W2766869345 hasAuthorship W2766869345A5074988967 @default.
- W2766869345 hasAuthorship W2766869345A5077492791 @default.
- W2766869345 hasAuthorship W2766869345A5082484204 @default.
- W2766869345 hasAuthorship W2766869345A5086936206 @default.
- W2766869345 hasBestOaLocation W27668693451 @default.
- W2766869345 hasConcept C121608353 @default.
- W2766869345 hasConcept C126322002 @default.
- W2766869345 hasConcept C134018914 @default.