Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766869999> ?p ?o ?g. }
- W2766869999 endingPage "402" @default.
- W2766869999 startingPage "398" @default.
- W2766869999 abstract "Objective The function of the exocrine pancreas is decreased in patients with type 1 diabetes but it is not known when this defect develops. The current study set out to determine whether the reduced exocrine function becomes manifest after the initiation of islet autoimmunity. Methods The study was nested in the prospective Type 1 Diabetes Prediction and Prevention study where children with human leukocyte antigen (HLA)-conferred susceptibility are observed from birth. Elastase-1 levels were analyzed from stool samples collected at the time of seroconversion to islet autoantibody positivity and at diagnosis of type 1 diabetes, as well as from samples taken from matched control children of similar age. Results Elastase levels were lower in case children at the time of the diagnosis of diabetes when compared to the control children. However, elastase concentrations did not differ between cases and controls at the time when autoantibodies appeared. Conclusion The results suggest that the defect in the exocrine function develops after the appearance of islet autoantibodies. Further studies are needed to assess whether reduced elastase levels predict rapid progression of islet autoimmunity to clinical disease." @default.
- W2766869999 created "2017-11-10" @default.
- W2766869999 creator A5000141478 @default.
- W2766869999 creator A5001640598 @default.
- W2766869999 creator A5010731818 @default.
- W2766869999 creator A5011722240 @default.
- W2766869999 creator A5034030410 @default.
- W2766869999 creator A5065652860 @default.
- W2766869999 creator A5066618511 @default.
- W2766869999 creator A5083267547 @default.
- W2766869999 creator A5085798200 @default.
- W2766869999 date "2017-10-17" @default.
- W2766869999 modified "2023-10-18" @default.
- W2766869999 title "Exocrine pancreas function decreases during the progression of the beta‐cell damaging process in young prediabetic children" @default.
- W2766869999 cites W1598021913 @default.
- W2766869999 cites W1874055151 @default.
- W2766869999 cites W1979105672 @default.
- W2766869999 cites W1993883803 @default.
- W2766869999 cites W1997562901 @default.
- W2766869999 cites W2042006477 @default.
- W2766869999 cites W2049781745 @default.
- W2766869999 cites W2067775036 @default.
- W2766869999 cites W2080019404 @default.
- W2766869999 cites W2085853044 @default.
- W2766869999 cites W2091573025 @default.
- W2766869999 cites W2097471898 @default.
- W2766869999 cites W2113217592 @default.
- W2766869999 cites W2114945507 @default.
- W2766869999 cites W2133745351 @default.
- W2766869999 cites W2158880005 @default.
- W2766869999 cites W2169845440 @default.
- W2766869999 cites W2595748443 @default.
- W2766869999 doi "https://doi.org/10.1111/pedi.12592" @default.
- W2766869999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29044779" @default.
- W2766869999 hasPublicationYear "2017" @default.
- W2766869999 type Work @default.
- W2766869999 sameAs 2766869999 @default.
- W2766869999 citedByCount "17" @default.
- W2766869999 countsByYear W27668699992018 @default.
- W2766869999 countsByYear W27668699992019 @default.
- W2766869999 countsByYear W27668699992020 @default.
- W2766869999 countsByYear W27668699992021 @default.
- W2766869999 countsByYear W27668699992022 @default.
- W2766869999 countsByYear W27668699992023 @default.
- W2766869999 crossrefType "journal-article" @default.
- W2766869999 hasAuthorship W2766869999A5000141478 @default.
- W2766869999 hasAuthorship W2766869999A5001640598 @default.
- W2766869999 hasAuthorship W2766869999A5010731818 @default.
- W2766869999 hasAuthorship W2766869999A5011722240 @default.
- W2766869999 hasAuthorship W2766869999A5034030410 @default.
- W2766869999 hasAuthorship W2766869999A5065652860 @default.
- W2766869999 hasAuthorship W2766869999A5066618511 @default.
- W2766869999 hasAuthorship W2766869999A5083267547 @default.
- W2766869999 hasAuthorship W2766869999A5085798200 @default.
- W2766869999 hasBestOaLocation W27668699991 @default.
- W2766869999 hasConcept C126322002 @default.
- W2766869999 hasConcept C134018914 @default.
- W2766869999 hasConcept C159654299 @default.
- W2766869999 hasConcept C163764329 @default.
- W2766869999 hasConcept C165220095 @default.
- W2766869999 hasConcept C181199279 @default.
- W2766869999 hasConcept C203014093 @default.
- W2766869999 hasConcept C2778764654 @default.
- W2766869999 hasConcept C2779134260 @default.
- W2766869999 hasConcept C2780130043 @default.
- W2766869999 hasConcept C2781044401 @default.
- W2766869999 hasConcept C2781232474 @default.
- W2766869999 hasConcept C55493867 @default.
- W2766869999 hasConcept C555293320 @default.
- W2766869999 hasConcept C71924100 @default.
- W2766869999 hasConcept C86803240 @default.
- W2766869999 hasConceptScore W2766869999C126322002 @default.
- W2766869999 hasConceptScore W2766869999C134018914 @default.
- W2766869999 hasConceptScore W2766869999C159654299 @default.
- W2766869999 hasConceptScore W2766869999C163764329 @default.
- W2766869999 hasConceptScore W2766869999C165220095 @default.
- W2766869999 hasConceptScore W2766869999C181199279 @default.
- W2766869999 hasConceptScore W2766869999C203014093 @default.
- W2766869999 hasConceptScore W2766869999C2778764654 @default.
- W2766869999 hasConceptScore W2766869999C2779134260 @default.
- W2766869999 hasConceptScore W2766869999C2780130043 @default.
- W2766869999 hasConceptScore W2766869999C2781044401 @default.
- W2766869999 hasConceptScore W2766869999C2781232474 @default.
- W2766869999 hasConceptScore W2766869999C55493867 @default.
- W2766869999 hasConceptScore W2766869999C555293320 @default.
- W2766869999 hasConceptScore W2766869999C71924100 @default.
- W2766869999 hasConceptScore W2766869999C86803240 @default.
- W2766869999 hasFunder F4320321108 @default.
- W2766869999 hasFunder F4320326518 @default.
- W2766869999 hasIssue "3" @default.
- W2766869999 hasLocation W27668699991 @default.
- W2766869999 hasLocation W27668699992 @default.
- W2766869999 hasLocation W27668699993 @default.
- W2766869999 hasOpenAccess W2766869999 @default.
- W2766869999 hasPrimaryLocation W27668699991 @default.
- W2766869999 hasRelatedWork W2017797235 @default.
- W2766869999 hasRelatedWork W2033958293 @default.
- W2766869999 hasRelatedWork W2035871243 @default.