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• W2766877270 abstract "Circulating tumor cells (CTCs) are extremely rare cells found in blood of metastatic cancer patients. There is a need for inexpensive technologies for fast enrichment of CTCs from large blood volumes. Previous data showed that antibody-conjugated lipid shell immuno-microbubbles (MBs) bind and isolate cells from biological fluids by flotation. Here, blood-stable MBs targeted to several surface markers for isolation of breast tumor cells were developed. MBs coated with anti-human EpCAM antibodies showed efficient binding of EpCAM+ breast cancer cell lines SKBR-3, MCF-7, and MDA-MB-453, whereas anti-human EGFR MBs showed binding of EpCAMLOW/NEGATIVE cell lines MDA-MB-231 and BT-549. Multitargeted anti-human EpCAM/EGFR MBs bound all cell lines with over 95% efficiency. Highly concentrated MB-bound tumor cells were collected in a microliter volume via an inverted vacuum-assisted harvesting setup. Using anti-EpCAM and/or anti-EpCAM/EGFR MBs, an efficient (70–90%) recovery and fast (30 min) isolation of the above-mentioned cells and cell clusters was achieved from 7.5 mL of spiked human blood. Using anti-EpCAM MBs and anti-EpCAM/EGFR MBs, cytokeratin-positive, CD45-negative CTCs were detected in 62.5% (10/16) of patients with metastatic breast cancer and CTC clusters were detected in 41.7% (5/12) of CTC-positive samples. Moreover, in some samples MBs isolated cytokeratin positive, CD45 negative tumor-derived microparticles. None of these structures were detected in blood from non-epithelial malignancies. The fast and inexpensive multitargeted platform for batch isolation of CTCs can promote research and clinical applications involving primary tumors and metastases." @default.
• W2766877270 created "2017-11-10" @default.
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• W2766877270 date "2018-01-01" @default.
• W2766877270 modified "2023-10-17" @default.
• W2766877270 title "Isolation of Breast cancer CTCs with multitargeted buoyant immunomicrobubbles" @default.
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• W2766877270 doi "https://doi.org/10.1016/j.colsurfb.2017.10.060" @default.
• W2766877270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5726926" @default.
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• W2766877270 hasPublicationYear "2018" @default.
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