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- W2766883421 endingPage "1103" @default.
- W2766883421 startingPage "1091" @default.
- W2766883421 abstract "Introduction: Cardiovascular disease (CVD) is the leading noncommunicable disease and main cause of death worldwide. Traditionally, blood has been the sample of choice for biomarker discovery, however, urine has roused great interest in recent years as a source of biomarkers. Sample collection is simple, non-invasive, and there is the possibility of implementing minimal cost tests in primary care settings.Areas covered: In this review, we systematically searched PubMed for proteomic studies of CVD, with the criteria that urine was included as a biological sample. Based on these criteria, and after manual curation, 47 research papers were included: 8 for coronary artery disease, 5 for angina, 15 for myocardial infarction, 23 for heart failure, and 4 for cerebrovascular disease.Expert commentary: Urinary biomarkers of early, asymptomatic stages of the disease would have a great impact on CVD morbidity and mortality, as widespread screening could be implemented at a reduced cost, allowing high-risk individuals to be identified and treated in a timely manner. An approach involving multiple biomarkers is necessary, as a single biomarker is unlikely to be sensitive/specific enough. By assessing a range of peptides there is the potential to detect changes in many pathways involved in the pathogenesis of CVDs." @default.
- W2766883421 created "2017-11-10" @default.
- W2766883421 creator A5047702239 @default.
- W2766883421 creator A5079273021 @default.
- W2766883421 date "2017-10-27" @default.
- W2766883421 modified "2023-09-23" @default.
- W2766883421 title "Urine protein biomarkers for detection of cardiovascular disease and their use for the clinic" @default.
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- W2766883421 doi "https://doi.org/10.1080/14789450.2017.1394188" @default.
- W2766883421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29041828" @default.
- W2766883421 hasPublicationYear "2017" @default.
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