Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766941260> ?p ?o ?g. }
- W2766941260 endingPage "21" @default.
- W2766941260 startingPage "1" @default.
- W2766941260 abstract "Since its discovery, ADAM17, also known as TNF α converting enzyme or TACE, is now known to process over 80 different substrates. Many of these substrates are mediators of cancer and inflammation. The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic. Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme. ADAM17 inhibitors have broad therapeutic potential, with properties ranging from tumor immunosurveillance and overcoming drug and radiation resistance in cancer, as treatments for cardiac hypertrophy and inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis. This review focuses on substrates and inhibitors identified more recently for ADAM17 and their role in cancer and inflammation." @default.
- W2766941260 created "2017-11-10" @default.
- W2766941260 creator A5017741352 @default.
- W2766941260 creator A5066256057 @default.
- W2766941260 date "2017-01-01" @default.
- W2766941260 modified "2023-10-13" @default.
- W2766941260 title "Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation" @default.
- W2766941260 cites W1168578519 @default.
- W2766941260 cites W1509151953 @default.
- W2766941260 cites W1512799118 @default.
- W2766941260 cites W1635741485 @default.
- W2766941260 cites W1665466173 @default.
- W2766941260 cites W1681870720 @default.
- W2766941260 cites W1734411634 @default.
- W2766941260 cites W177079745 @default.
- W2766941260 cites W1819850574 @default.
- W2766941260 cites W1823800789 @default.
- W2766941260 cites W1899539805 @default.
- W2766941260 cites W1920087348 @default.
- W2766941260 cites W1920103782 @default.
- W2766941260 cites W1956736834 @default.
- W2766941260 cites W1963940744 @default.
- W2766941260 cites W1965147884 @default.
- W2766941260 cites W1966128754 @default.
- W2766941260 cites W1966339320 @default.
- W2766941260 cites W1967561054 @default.
- W2766941260 cites W1970133527 @default.
- W2766941260 cites W1970535801 @default.
- W2766941260 cites W1973693466 @default.
- W2766941260 cites W1978607785 @default.
- W2766941260 cites W1980408283 @default.
- W2766941260 cites W1980717479 @default.
- W2766941260 cites W1981221499 @default.
- W2766941260 cites W1982680945 @default.
- W2766941260 cites W1984467626 @default.
- W2766941260 cites W1984924483 @default.
- W2766941260 cites W1990360580 @default.
- W2766941260 cites W1990601892 @default.
- W2766941260 cites W1993248218 @default.
- W2766941260 cites W1994499776 @default.
- W2766941260 cites W1994924350 @default.
- W2766941260 cites W1996134285 @default.
- W2766941260 cites W1997005830 @default.
- W2766941260 cites W1997091177 @default.
- W2766941260 cites W1999242469 @default.
- W2766941260 cites W2002388143 @default.
- W2766941260 cites W2008950670 @default.
- W2766941260 cites W2009802325 @default.
- W2766941260 cites W2013177587 @default.
- W2766941260 cites W2014463647 @default.
- W2766941260 cites W2015567053 @default.
- W2766941260 cites W2018275608 @default.
- W2766941260 cites W2021920896 @default.
- W2766941260 cites W2023412733 @default.
- W2766941260 cites W2024402718 @default.
- W2766941260 cites W2024786569 @default.
- W2766941260 cites W2025559305 @default.
- W2766941260 cites W2026859850 @default.
- W2766941260 cites W2027526894 @default.
- W2766941260 cites W2027565221 @default.
- W2766941260 cites W2027615892 @default.
- W2766941260 cites W2028945916 @default.
- W2766941260 cites W2030277145 @default.
- W2766941260 cites W2033403479 @default.
- W2766941260 cites W2035370541 @default.
- W2766941260 cites W2036361515 @default.
- W2766941260 cites W2036797607 @default.
- W2766941260 cites W2036842448 @default.
- W2766941260 cites W2037753872 @default.
- W2766941260 cites W2038578669 @default.
- W2766941260 cites W2041233605 @default.
- W2766941260 cites W2047065833 @default.
- W2766941260 cites W2048356493 @default.
- W2766941260 cites W2051268134 @default.
- W2766941260 cites W2052413435 @default.
- W2766941260 cites W2053009900 @default.
- W2766941260 cites W2053832323 @default.
- W2766941260 cites W2054673682 @default.
- W2766941260 cites W2056601905 @default.
- W2766941260 cites W2058729725 @default.
- W2766941260 cites W2060169824 @default.
- W2766941260 cites W2061943904 @default.
- W2766941260 cites W2062784484 @default.
- W2766941260 cites W2064152387 @default.
- W2766941260 cites W2065201852 @default.
- W2766941260 cites W2072219853 @default.
- W2766941260 cites W2072679727 @default.
- W2766941260 cites W2074635352 @default.
- W2766941260 cites W2074881372 @default.
- W2766941260 cites W2075663237 @default.
- W2766941260 cites W2075765831 @default.
- W2766941260 cites W2076379612 @default.
- W2766941260 cites W2076757423 @default.
- W2766941260 cites W2077173577 @default.
- W2766941260 cites W2078269233 @default.
- W2766941260 cites W2079004196 @default.
- W2766941260 cites W2079634002 @default.
- W2766941260 cites W2081561119 @default.