Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766957068> ?p ?o ?g. }
- W2766957068 endingPage "232" @default.
- W2766957068 startingPage "225" @default.
- W2766957068 abstract "Abstract The role of serine in metabolic processes has recently attracted much attention as it could be used for the biosynthesis of purine, sphingolipids, and glutathione. The present study was conducted to investigate the effects of serine on LPS-induced intestinal inflammation and barrier dysfunction. The results showed that pretreatment with serine prevented the LPS-induced inflammatory response and oxidative stress both in vivo and in vitro. Moreover, serine maintained intestinal barrier function and permeability. In addition, we found that serine improved glutathione synthesis and AMP-activated protein kinase (AMPK) activity. However, following the small interfering RNA (siRNA) inhibition of p53 expression or inhibition of glutathione synthesis in IPEC-1 cells, the protective effects of serine on LPS-induced damage were diminished. Our results indicated that serine may prevent LPS-induced damage in the intestine by improving glutathione synthesis and AMPK activity in a p53-dependent manner." @default.
- W2766957068 created "2017-11-10" @default.
- W2766957068 creator A5008929986 @default.
- W2766957068 creator A5016410321 @default.
- W2766957068 creator A5042511913 @default.
- W2766957068 creator A5058637832 @default.
- W2766957068 creator A5066018914 @default.
- W2766957068 creator A5085716461 @default.
- W2766957068 creator A5090845983 @default.
- W2766957068 date "2017-12-01" @default.
- W2766957068 modified "2023-10-15" @default.
- W2766957068 title "Serine prevents LPS-induced intestinal inflammation and barrier damage via p53-dependent glutathione synthesis and AMPK activation" @default.
- W2766957068 cites W1527079125 @default.
- W2766957068 cites W1966776937 @default.
- W2766957068 cites W1977104985 @default.
- W2766957068 cites W1980181091 @default.
- W2766957068 cites W1997939016 @default.
- W2766957068 cites W2022892655 @default.
- W2766957068 cites W2024979614 @default.
- W2766957068 cites W2025270538 @default.
- W2766957068 cites W2030479855 @default.
- W2766957068 cites W2053527204 @default.
- W2766957068 cites W2073966685 @default.
- W2766957068 cites W2080627209 @default.
- W2766957068 cites W2098354374 @default.
- W2766957068 cites W2113290646 @default.
- W2766957068 cites W2115144412 @default.
- W2766957068 cites W2115957809 @default.
- W2766957068 cites W2134606435 @default.
- W2766957068 cites W2135138589 @default.
- W2766957068 cites W2145189896 @default.
- W2766957068 cites W2150631942 @default.
- W2766957068 cites W2156221444 @default.
- W2766957068 cites W2162932896 @default.
- W2766957068 cites W2220057318 @default.
- W2766957068 cites W2230238676 @default.
- W2766957068 cites W2239475905 @default.
- W2766957068 cites W2256338503 @default.
- W2766957068 cites W2322503608 @default.
- W2766957068 cites W2572784418 @default.
- W2766957068 cites W2579054962 @default.
- W2766957068 doi "https://doi.org/10.1016/j.jff.2017.10.026" @default.
- W2766957068 hasPublicationYear "2017" @default.
- W2766957068 type Work @default.
- W2766957068 sameAs 2766957068 @default.
- W2766957068 citedByCount "36" @default.
- W2766957068 countsByYear W27669570682018 @default.
- W2766957068 countsByYear W27669570682019 @default.
- W2766957068 countsByYear W27669570682020 @default.
- W2766957068 countsByYear W27669570682021 @default.
- W2766957068 countsByYear W27669570682022 @default.
- W2766957068 countsByYear W27669570682023 @default.
- W2766957068 crossrefType "journal-article" @default.
- W2766957068 hasAuthorship W2766957068A5008929986 @default.
- W2766957068 hasAuthorship W2766957068A5016410321 @default.
- W2766957068 hasAuthorship W2766957068A5042511913 @default.
- W2766957068 hasAuthorship W2766957068A5058637832 @default.
- W2766957068 hasAuthorship W2766957068A5066018914 @default.
- W2766957068 hasAuthorship W2766957068A5085716461 @default.
- W2766957068 hasAuthorship W2766957068A5090845983 @default.
- W2766957068 hasConcept C11960822 @default.
- W2766957068 hasConcept C181199279 @default.
- W2766957068 hasConcept C185592680 @default.
- W2766957068 hasConcept C203014093 @default.
- W2766957068 hasConcept C2776414213 @default.
- W2766957068 hasConcept C2776914184 @default.
- W2766957068 hasConcept C2780124434 @default.
- W2766957068 hasConcept C538909803 @default.
- W2766957068 hasConcept C55493867 @default.
- W2766957068 hasConcept C86803240 @default.
- W2766957068 hasConcept C95444343 @default.
- W2766957068 hasConcept C97029542 @default.
- W2766957068 hasConceptScore W2766957068C11960822 @default.
- W2766957068 hasConceptScore W2766957068C181199279 @default.
- W2766957068 hasConceptScore W2766957068C185592680 @default.
- W2766957068 hasConceptScore W2766957068C203014093 @default.
- W2766957068 hasConceptScore W2766957068C2776414213 @default.
- W2766957068 hasConceptScore W2766957068C2776914184 @default.
- W2766957068 hasConceptScore W2766957068C2780124434 @default.
- W2766957068 hasConceptScore W2766957068C538909803 @default.
- W2766957068 hasConceptScore W2766957068C55493867 @default.
- W2766957068 hasConceptScore W2766957068C86803240 @default.
- W2766957068 hasConceptScore W2766957068C95444343 @default.
- W2766957068 hasConceptScore W2766957068C97029542 @default.
- W2766957068 hasFunder F4320321001 @default.
- W2766957068 hasFunder F4320322866 @default.
- W2766957068 hasFunder F4320335777 @default.
- W2766957068 hasLocation W27669570681 @default.
- W2766957068 hasOpenAccess W2766957068 @default.
- W2766957068 hasPrimaryLocation W27669570681 @default.
- W2766957068 hasRelatedWork W2013902311 @default.
- W2766957068 hasRelatedWork W2039126524 @default.
- W2766957068 hasRelatedWork W2049037526 @default.
- W2766957068 hasRelatedWork W2060798428 @default.
- W2766957068 hasRelatedWork W2915648405 @default.
- W2766957068 hasRelatedWork W3109772286 @default.
- W2766957068 hasRelatedWork W3205542736 @default.
- W2766957068 hasRelatedWork W4290000927 @default.