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- W2767036969 abstract "Cerebral microbleeds (CMBs), detected on brain MRI, are a risk factor for intracerebral hemorrhage. The objectives of this study were to determine the frequency of CMBs and the associations with amyloid burden on PET in a population-based sample. We analyzed 1098 Mayo Clinic Study of Aging participants age 60 years and older (53% male) with 3T MRI scans with T2* Gradient recall echo sequences from October 2011-December 2016. One thousand twenty two (93%) underwent 11C-Pittsburgh Compound-B (PiB) PET scans. We performed logistic regression analyses to examine the relation between demographic factors and odds of CMBs. We then used multiple regression analyses to examine the relationship between lobar CMB, which have been associated with the presence of cerebral amyloid angiopathy, and deep CMBs, which have been associated with hypertensive small vessel disease, with log PIB SUVr. Two hundred thirty seven participants (21.6%) had at least one CMB. CMB frequency increased with age decade, from 11% in persons aged 60 to 69 years to 40% in participants of 80 years and older (Figure). Two or more CMBs occurred in 102 (9.3%) participants. Male sex (odds ratio (OR) (95% confidence intervals [CI] 1.97 (1.43, 2.72), p<0.001) and APOE e 4 homozygosity (3.28 (1.27, 8.45), p=0.01) were associated with increased odds of having a CMB. In a subsequent multiple regression analysis after adjusting for age, sex, and APOE4 carrier status, the presence of lobar (Beta [β] = 0.006, p=0.015), but not deep CMBs (β= 0.011, p=0.45) was associated with greater PiB SUVR. Cerebral microbleed frequency by decade and location." @default.
- W2767036969 created "2017-11-10" @default.
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- W2767036969 date "2017-07-01" @default.
- W2767036969 modified "2023-09-27" @default.
- W2767036969 title "CEREBRAL MICROBLEEDS AND AMYLOID BURDEN: THE MAYO CLINIC STUDY OF AGING" @default.
- W2767036969 doi "https://doi.org/10.1016/j.jalz.2017.07.440" @default.
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