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- W2767071503 abstract "Regulated exocytosis by secretory organelles is important for malaria parasite invasion and egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed both pre- and postexocytosis. Here we report the multistage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine-based scaffold compound 49c. This scaffold inhibits the preexocytosis processing of several secreted rhoptry and microneme proteins by targeting the corresponding maturases plasmepsins IX (PMIX) and X (PMX), respectively. Conditional excision of PMIX revealed its crucial role in invasion, and recombinantly active PMIX and PMX cleave egress and invasion factors in a 49c-sensitive manner." @default.
- W2767071503 created "2017-11-10" @default.
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- W2767071503 date "2017-10-27" @default.
- W2767071503 modified "2023-10-17" @default.
- W2767071503 title "A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress" @default.
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- W2767071503 cites W2026920658 @default.
- W2767071503 cites W2034720263 @default.
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- W2767071503 doi "https://doi.org/10.1126/science.aaf8675" @default.
- W2767071503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5730047" @default.
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