FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767090073> ?p ?o ?g. }

• W2767090073 abstract "Members of the STAT transcription factor family are expressed in adipocytes, including STATs 1, 3, 5A, 5B, and 6. Although STATs 1 and 5 proteins are known to be induced during adipogenesis, the functions of these STATs in mature adipocytes are not known. Hence we have sought to identify adipocyte genes which are transcriptionally regulated by STATs to elucidate a role of these proteins in fat cells. We have characterized STAT binding sites in the promoters of four adipocyte genes, PPARγ2, LPL, FAS and C/EBPδ. PPARγ2 expression decreases in adipocytes following exposure to IFNγ, an activator of STAT1. IFNγ induces the binding of STAT1 to a site in the PPARγ2 promoter. Furthermore, the STAT1 binding site is required for IFNγ regulation of the PPARγ2 promoter in vitro. Although CT-1 and LIF induced STAT1 binding to the PPARγ2 promoter, only CT-1 substantially modulated expression of PPARγ2. We have also identified a STAT1 binding site in the promoter of LPL, which is bound by STAT1 following treatment of 3T3-L1 adipocytes with IFNγ. In addition, LPL protein levels are downregulated by IFNγ treatment. Treatment with PRL, an activator of STAT5A, decreased levels of FAS protein and mRNA in adipocytes. Regulation of the rat FAS promoter by PRL required a region of the promoter which contained a STAT5 binding site. Binding to this site by STAT5A was activated by PRL treatment and was highly specific. Finally, in our analysis on the effects of LIF on adipocytes, we determined that the expression SOCS3 and C/EBPδ mRNA transiently increases following treatment of adipocytes with LIF. We identified three STAT1 binding sites within the C/EBPδ promoter, which we hypothesize mediate the induction of C/EBPδ by LIF. Although LIF did not profoundly affect adipogenesis or basal and insulin-stimulated glucose uptake, chronic treatment with LIF abrogated the level of SREBP1 and FAS proteins. In summary, our studies suggest that STAT1 and STAT5 serve to limit synthesis of lipids in mature fat cells, limiting expansion of adipocytes and accretion of adipose tissue. The identification of PPARγ, FAS, and LPL as STAT-regulated genes provides insight into the molecular mechanisms of energy homeostasis, adipocyte physiology and the action of cytokines in fat." @default.
• W2767090073 created "2017-11-10" @default.
• W2767090073 creator A5064551886 @default.
• W2767090073 date "2022-06-10" @default.
• W2767090073 modified "2023-10-15" @default.
• W2767090073 title "Modulation of adipocyte genes by signal transducers and activators of transcription" @default.
• W2767090073 cites W103687069 @default.
• W2767090073 cites W127609430 @default.
• W2767090073 cites W1488559297 @default.
• W2767090073 cites W1492344672 @default.
• W2767090073 cites W1499501743 @default.
• W2767090073 cites W1523909433 @default.
• W2767090073 cites W1572402792 @default.
• W2767090073 cites W1587875569 @default.
• W2767090073 cites W1587876647 @default.
• W2767090073 cites W1597210981 @default.
• W2767090073 cites W1602943807 @default.
• W2767090073 cites W1603378909 @default.
• W2767090073 cites W1647782814 @default.
• W2767090073 cites W1675830194 @default.
• W2767090073 cites W1680690327 @default.
• W2767090073 cites W1694771231 @default.
• W2767090073 cites W1832383799 @default.
• W2767090073 cites W1839417013 @default.
• W2767090073 cites W1843523988 @default.
• W2767090073 cites W1857574091 @default.
• W2767090073 cites W1882868104 @default.
• W2767090073 cites W1892131812 @default.
• W2767090073 cites W1907219612 @default.
• W2767090073 cites W1938499452 @default.
• W2767090073 cites W1939477527 @default.
• W2767090073 cites W1943273005 @default.
• W2767090073 cites W1946831939 @default.
• W2767090073 cites W1965464733 @default.
• W2767090073 cites W1967486091 @default.
• W2767090073 cites W1968514890 @default.
• W2767090073 cites W1968754277 @default.
• W2767090073 cites W1969218281 @default.
• W2767090073 cites W1970664882 @default.
• W2767090073 cites W1971977518 @default.
• W2767090073 cites W1972527945 @default.
• W2767090073 cites W1974544823 @default.
• W2767090073 cites W1975276753 @default.
• W2767090073 cites W1976315274 @default.
• W2767090073 cites W1977603767 @default.
• W2767090073 cites W1980338370 @default.
• W2767090073 cites W1980401339 @default.
• W2767090073 cites W1980756034 @default.
• W2767090073 cites W1982659014 @default.
• W2767090073 cites W1983565654 @default.
• W2767090073 cites W1984334223 @default.
• W2767090073 cites W1984540781 @default.
• W2767090073 cites W1985995289 @default.
• W2767090073 cites W1989535960 @default.
• W2767090073 cites W1991836743 @default.
• W2767090073 cites W1991882271 @default.
• W2767090073 cites W1992604455 @default.
• W2767090073 cites W1993520606 @default.
• W2767090073 cites W1993583458 @default.
• W2767090073 cites W1994167267 @default.
• W2767090073 cites W1995176683 @default.
• W2767090073 cites W1995258511 @default.
• W2767090073 cites W1996235842 @default.
• W2767090073 cites W1996661845 @default.
• W2767090073 cites W1998464620 @default.
• W2767090073 cites W1998919487 @default.
• W2767090073 cites W1999028040 @default.
• W2767090073 cites W2000333547 @default.
• W2767090073 cites W2000821877 @default.
• W2767090073 cites W2000867519 @default.
• W2767090073 cites W2000973674 @default.
• W2767090073 cites W2001668845 @default.
• W2767090073 cites W2002246876 @default.
• W2767090073 cites W2002519246 @default.
• W2767090073 cites W2002898689 @default.
• W2767090073 cites W2004861205 @default.
• W2767090073 cites W2005902803 @default.
• W2767090073 cites W2008077083 @default.
• W2767090073 cites W2008513160 @default.
• W2767090073 cites W2008933908 @default.
• W2767090073 cites W2009480208 @default.
• W2767090073 cites W2010255616 @default.
• W2767090073 cites W2011030679 @default.
• W2767090073 cites W2012354624 @default.
• W2767090073 cites W2013325898 @default.
• W2767090073 cites W2013427049 @default.
• W2767090073 cites W2013687936 @default.
• W2767090073 cites W2015812049 @default.
• W2767090073 cites W2016587287 @default.
• W2767090073 cites W2018855387 @default.
• W2767090073 cites W2019371323 @default.
• W2767090073 cites W2021365028 @default.
• W2767090073 cites W2021951421 @default.
• W2767090073 cites W2022123949 @default.
• W2767090073 cites W2024448363 @default.
• W2767090073 cites W2025236720 @default.
• W2767090073 cites W2025846514 @default.
• W2767090073 cites W2026109879 @default.
• W2767090073 cites W2026512448 @default.
• W2767090073 cites W2027495994 @default.

• next