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• W2767096051 abstract "1417 Electrochemotherapy is an antitumor therapy that utilizes chemotherapy combined with locally delivered short intense direct current electric pulse to the tumor nodule in order to enhance drug delivery into the cells. The aim of the present study was to evaluate the electrochemotherapy treatment of perianal tumors of different sizes in dogs. Between March 2000 and July 2003, 12 patients with all together 26 measurable cutaneous nodules were included in the study. Before treatment, the dogs were sedated. Electrochemotherapy consisted of intratumoral administration of cisplatin at a dose of approx. 1 mg/cm 3 tumor volume, followed by application of electric pulses to the tumor. If the treatment with cisplatin as the first chemotherapeutic drug was not successful, electrochemotherapy with bleomycin was performed; at a dose of approx. 3 mg/1 cm 3 tumor volume. Square wave electric pulses of 100 μs, 910 V amplitude, frequency 1 Hz were delivered through two parallel stainless steel electrodes (inner distance between them 7 mm) with an electroporator Jouan GHT 1287. Each run of electric pulses was delivered in two trains of 4 pulses, with 1 s interval, in two perpendicular directions. The interval between cisplatin or bleomycin administration and the application of electric pulses was 1-2 min. The treatment response was evaluated according to WHO classification (complete response (CR); partial response (PR); no change (NC) and progressive disease (PD)). The number of objective responses (OR) was determined by combining the number of CR and PR. Responses to treatment were assessed 4 weeks after the therapy, 82% of all tumors treated with electrochemotherapy responded with objective response (OR) (CR = 41%, PR = 41%), 16% responded with NC and one tumor (2%) went in PD. At the end of observation period for each tumor ranging from 1 to 34 months, 92% of OR (CR=65%, PR=27%), 8% of NC and no PD were obtained. To achieve above-mentioned results, average number of electrochemotherapy sessions was 1.6 and in range from 1 to maximum 4 sessions per patient. There were no major local or general side effects noted. This study shows that electrochemotherapy with cisplatin or bleomycin is an effective treatment of perianal tumors in dogs. The advantages of this therapy are it’s simplicity, short duration of treatment sessions, low chemotherapeutic doses, and insignificant side effects, as well as the fact that it can be performed on outpatient basis." @default.
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• W2767096051 date "2005-05-01" @default.
• W2767096051 modified "2023-09-27" @default.
• W2767096051 title "Effective treatment of perianal tumors in dogs by electrochemotherapy" @default.
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