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- W2767110894 endingPage "570" @default.
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- W2767110894 abstract "It is disappointing that only a few patients with hepatocellular carcinoma (HCC) obtain a significant survival benefit from the sorafenib treatment, which is currently regarded as a first-line chemotherapeutic therapy in patients with advanced HCC. Most patients are highly refractory to this therapy. Therefore, it is necessary to identify resistant factors and explore potential protocols that can be used to overcome the resistance or substitute sorafenib once the resistance is formed. In fact, a growing body of studies has been focusing on the resistance mechanisms or the method to overcome it. The limitation of sorafenib efficacy has been partially but not fully elucidated. Moreover, some protocols have shown encouraging outcomes but still need to be further verified in clinical trials. In this review, we summarize the recent findings on the potential mechanisms that contribute to sorafenib resistance and discuss strategies that can be used to improve the treatment outcome." @default.
- W2767110894 created "2017-11-10" @default.
- W2767110894 creator A5000119502 @default.
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- W2767110894 creator A5089417570 @default.
- W2767110894 creator A5091326573 @default.
- W2767110894 date "2017-12-01" @default.
- W2767110894 modified "2023-10-05" @default.
- W2767110894 title "New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies" @default.
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