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- W2767128444 abstract "Information derived from biomarkers improves detection of AD pathology years before symptoms appear. Despite known contributions of biomarkers to AD research, a major drawback is the willingness of participants to undergo a lumbar puncture (LP). Data on factors affecting participation in LP studies are limited. We examined effects of socio-demographic variables and concerns related to trust in medical research on expressed likelihood to participate in research involving blood or CSF donation. Item responses to a comprehensive survey questionnaire from a diverse sample of 410 adults (mean age=44.7, SD=16.7) were used in the analysis. The sample included 25.6% African Americans, 24.4% Latinos, 24.4% American Indians, 24.6% Whites. The likelihood of providing blood or CSF samples was rated using a 5 pt scale ranging from “Very Likely “to “Very Unlikely”. Chi Square analyses evaluated associations of ethnic/racial background, trust in medical researchers, concerns about physical pain and infection, having a family member with AD, age, and gender on likelihood of providing blood or CSF samples. There was no significant association between ethnicity/race and likelihood to provide blood samples (p=0.027), 61 % of respondents were “very or somewhat likely” to provide blood. In contrast, only 17 % of the sample was “very or somewhat likely” to provide CSF and associations between ethnicity/race and likelihood to provide CSF approached significance (p=0.06). Concern about pain and trust (p=0.000) in medical researchers (p=0.000) decreased likelihood to provide CSF. Respondents more willing to provide blood were also more likely to provide CSF (p=0.00). Younger respondents were less willing to provide CSF than older respondents (p=0.030); Latinos expressed greater likelihood to participate in CSF studies than Whites (p=0.017). Respondents with higher educational levels were less likely to provide CSF samples than respondents with lower education (p=0.016). Having a family member with AD did not influence likelihood to provide blood or CSF. Although overall willingness to provide CSF was low, we found interesting and unexpected variations among racial/ethnic groups. Results suggest common and group specific barriers to LP studies. These issues that can inform tailored recruitment strategies designed to increase the propensity of CSF donation." @default.
- W2767128444 created "2017-11-10" @default.
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- W2767128444 date "2017-07-01" @default.
- W2767128444 modified "2023-09-27" @default.
- W2767128444 title "[P4-331]: ARE MEMBERS OF UNDERREPRESENTED GROUPS REALLY LESS LIKELY TO PARTICIPATE IN BIOMARKER STUDIES REQUESTING BLOOD OR CSF ?" @default.
- W2767128444 doi "https://doi.org/10.1016/j.jalz.2017.06.2201" @default.
- W2767128444 hasPublicationYear "2017" @default.
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