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- W2767222762 abstract "Neuroblastoma is a rare cancer arising in the embryonic stage, originating from the neural crest. It originates from any region of the central nervous system, but often emerges from the adrenal glands. In most cases, metastasis to lymph nodes, bone marrow, and bone affect survival rates adversely. Although neuroblastoma is considered as a completely familial disease at the beginning, familial cases constitute a small part of all cases. The major mutations identified in the pathogenesis of neuroblastoma include MYCN, ALK, PHOX2B, ATRX and TERT genes. Nevertheless, it is now known that not only genetic but also epigenetic aberrations of gene expression are involved in the pathogenesis of neuroblastoma as well as many other diseases. Epigenetic regulations which include histone modifications that regulate the chromatin structure; DNA methylation which is involved in the control of gene expression; and ncRNAs, is being searched in relation to neuroblastoma. Conventional treatment includes surgical removal of tumors, chemotherapy, autologous stem cell transplantation, radiotherapy approaches according to the prognostic features of the patients, however, resistance to chemotherapeutics or insensitivity problems frequently occur. Current treatment options have focused on the development of ''targeted treatment'' approaches which is aimed at directly eliminating cancer cells in order to improve survival rates and the quality of life. This study aims to reveal our knowledge of neuroblastoma genetics and epigenetics and where we are in targeted treatment approaches with up-to date literatures." @default.
- W2767222762 created "2017-11-17" @default.
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- W2767222762 date "2017-01-01" @default.
- W2767222762 modified "2023-10-18" @default.
- W2767222762 title "Neuroblastoma: Genetic, Epigenetic Mechanisms and Targeted Therapy Approaches: Review" @default.
- W2767222762 doi "https://doi.org/10.5336/neuro.2017-57599" @default.
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