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- W2767228411 abstract "Growth in healthy children is associated with changes in bone density and microarchitecture. Trabecular morphology is an additional important determinant of bone strength, but little is currently known about trabecular morphology in healthy young people. To investigate associations of trabecular morphology with increasing maturity and with body composition in healthy girls. Cross-sectional study. Academic research center. Eighty-six healthy girls aged 9 to 18 years. High-resolution peripheral quantitative computed tomography and individual trabecula segmentation were used to assess volumetric bone density, microarchitecture, and trabecular morphology (plate-like vs rod-like) at the distal radius and tibia. Plate-like bone volume divided by total volume (pBV/TV) increased statistically significantly at the tibia (R = 0.41, P < 0.001), whereas rod-like BV/TV (rBV/TV) decreased statistically significantly at both the radius and tibia (R = −0.34, P = 0.003 and R = −0.28, P = 0.008, respectively) with increasing bone age. In multivariable models, lean mass positively correlated with pBV/TV and plate number at the radius and with plate thickness at both sites. In contrast, fat mass negatively correlated with plate thickness at the tibia and plate surface at both sites. In addition, fat mass positively correlated with rBV/TV and number at the tibia. pBV/TV at both the distal radius and tibia was positively correlated with spine bone mineral density. Increasing maturity across late childhood and adolescence is associated with changes in trabecular morphology anticipated to contribute to bone strength. Body composition correlates with trabecular morphology, suggesting that muscle mass and adiposity in youth may contribute to long-term skeletal health." @default.
- W2767228411 created "2017-11-17" @default.
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- W2767228411 date "2017-11-07" @default.
- W2767228411 modified "2023-10-18" @default.
- W2767228411 title "Trabecular Bone Morphology Correlates With Skeletal Maturity and Body Composition in Healthy Adolescent Girls" @default.
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- W2767228411 doi "https://doi.org/10.1210/jc.2017-01785" @default.
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