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• W2767250689 endingPage "e12807" @default.
• W2767250689 startingPage "e12807" @default.
• W2767250689 abstract "Trypanosoma cruzi is the kinetoplastid protozoan parasite that causes human Chagas disease, a chronic disease with complex outcomes including severe cardiomyopathy and sudden death. In mammalian hosts, T. cruzi colonises a wide range of tissues and cell types where it replicates within the host cell cytoplasm. Like all intracellular pathogens, T. cruzi amastigotes must interact with its immediate host cell environment in a manner that facilitates access to nutrients and promotes a suitable niche for replication and survival. Although potentially exploitable to devise strategies for pathogen control, fundamental knowledge of the host pathways co-opted by T. cruzi during infection is currently lacking. Here, we report that intracellular T. cruzi amastigotes establish close contact with host mitochondria via their single flagellum. Given the key bioenergetic and homeostatic roles of mitochondria, this striking finding suggests a functional role for host mitochondria in the infection process and points to the T. cruzi amastigote flagellum as an active participant in pathogenesis. Our study establishes the basis for future investigation of the molecular and functional consequences of this intriguing host–parasite interaction." @default.
• W2767250689 created "2017-11-17" @default.
• W2767250689 creator A5036584800 @default.
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• W2767250689 date "2017-11-28" @default.
• W2767250689 modified "2023-09-25" @default.
• W2767250689 title "Targeting host mitochondria: A role for the<i>Trypanosoma cruzi</i>amastigote flagellum" @default.
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• W2767250689 doi "https://doi.org/10.1111/cmi.12807" @default.
• W2767250689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5764780" @default.
• W2767250689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29119655" @default.
• W2767250689 hasPublicationYear "2017" @default.
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