FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767250873> ?p ?o ?g. }

• W2767250873 endingPage "100" @default.
• W2767250873 startingPage "94" @default.
• W2767250873 abstract "The disposition dose of clopidogrel is different in CYP2C19*2 gene carriers and non-carriers. High-dose clopidogrel has been recommended to overcome a low-responsiveness to clopidogrel in patients with the CYP2C19*2 gene. To guide the choice of clopidogrel dosage and catalyse a development in the field of personalized therapy, we developed an ultrasensitive electrochemical biosensor to detect CYP2C19*2 gene. We constructed a novel assay based on cerium dioxide (CeO2)-functionalized carboxyl fullerene (c-C60) supported by Pt nanoparticles (c-C60/CeO2/PtNPs) for signal amplification. Au nanoparticles @ Fe-MIL-88NH2 ([email protected]) were synthesized by one-step method as the support platform to enhance the conductivity and immobilize more biotin-modified capture probe (bio-CP) through the superior affinity and specificity between streptavidin and biotin. c-C60/CeO2/PtNPs were labeled with signal probe to form the signal label. After the sandwich reaction of CYP2C19*2 gene between capture probe and the signal label, a distinguishing electrochemical signal from the catalysis of H2O2 by signal label would be observed. Amperometry was applied to record electrochemical signals. Under optimized conditions, the approach showed a good linear dependence between current and the logarithm of CYP2C19*2 gene concentrations in the range of 1 fM to 50 nM with a low detection limit of 0.33 fM (S/N = 3). The proposed method showed good specificity to target DNA compared with possible interfering substances. More importantly, the fabricated biosensor achieved accurate quantitative detection of CYP2C19*2 gene in human serum samples demonstrated by excellent correlations with standard DNA sequencing and provided a promising strategy for electrochemical biosensor detection of other gene mutations." @default.
• W2767250873 created "2017-11-17" @default.
• W2767250873 creator A5001880744 @default.
• W2767250873 creator A5026233281 @default.
• W2767250873 creator A5034894369 @default.
• W2767250873 creator A5036539822 @default.
• W2767250873 creator A5053397364 @default.
• W2767250873 creator A5082857859 @default.
• W2767250873 creator A5084161318 @default.
• W2767250873 date "2018-04-01" @default.
• W2767250873 modified "2023-10-04" @default.
• W2767250873 title "Cerium dioxide-doped carboxyl fullerene as novel nanoprobe and catalyst in electrochemical biosensor for amperometric detection of the CYP2C19*2 allele in human serum" @default.
• W2767250873 cites W1582308320 @default.
• W2767250873 cites W168371622 @default.
• W2767250873 cites W1971432776 @default.
• W2767250873 cites W1980737014 @default.
• W2767250873 cites W1990122446 @default.
• W2767250873 cites W1993518253 @default.
• W2767250873 cites W1999694583 @default.
• W2767250873 cites W2001141842 @default.
• W2767250873 cites W2002686689 @default.
• W2767250873 cites W2011578396 @default.
• W2767250873 cites W2020099077 @default.
• W2767250873 cites W2026222911 @default.
• W2767250873 cites W2037355442 @default.
• W2767250873 cites W2044770851 @default.
• W2767250873 cites W2059850055 @default.
• W2767250873 cites W2067047345 @default.
• W2767250873 cites W2087923279 @default.
• W2767250873 cites W2119186881 @default.
• W2767250873 cites W2135575592 @default.
• W2767250873 cites W2149054217 @default.
• W2767250873 cites W2170561696 @default.
• W2767250873 cites W2214597303 @default.
• W2767250873 cites W2254459549 @default.
• W2767250873 cites W2263162213 @default.
• W2767250873 cites W2465356535 @default.
• W2767250873 cites W2528246186 @default.
• W2767250873 cites W2546590071 @default.
• W2767250873 cites W2585685499 @default.
• W2767250873 cites W3030817736 @default.
• W2767250873 doi "https://doi.org/10.1016/j.bios.2017.11.014" @default.
• W2767250873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29127901" @default.
• W2767250873 hasPublicationYear "2018" @default.
• W2767250873 type Work @default.
• W2767250873 sameAs 2767250873 @default.
• W2767250873 citedByCount "42" @default.
• W2767250873 countsByYear W27672508732018 @default.
• W2767250873 countsByYear W27672508732019 @default.
• W2767250873 countsByYear W27672508732020 @default.
• W2767250873 countsByYear W27672508732021 @default.
• W2767250873 countsByYear W27672508732022 @default.
• W2767250873 countsByYear W27672508732023 @default.
• W2767250873 crossrefType "journal-article" @default.
• W2767250873 hasAuthorship W2767250873A5001880744 @default.
• W2767250873 hasAuthorship W2767250873A5026233281 @default.
• W2767250873 hasAuthorship W2767250873A5034894369 @default.
• W2767250873 hasAuthorship W2767250873A5036539822 @default.
• W2767250873 hasAuthorship W2767250873A5053397364 @default.
• W2767250873 hasAuthorship W2767250873A5082857859 @default.
• W2767250873 hasAuthorship W2767250873A5084161318 @default.
• W2767250873 hasConcept C119128265 @default.
• W2767250873 hasConcept C139369640 @default.
• W2767250873 hasConcept C147789679 @default.
• W2767250873 hasConcept C155672457 @default.
• W2767250873 hasConcept C160756335 @default.
• W2767250873 hasConcept C16387964 @default.
• W2767250873 hasConcept C171250308 @default.
• W2767250873 hasConcept C17525397 @default.
• W2767250873 hasConcept C185592680 @default.
• W2767250873 hasConcept C192562407 @default.
• W2767250873 hasConcept C21951064 @default.
• W2767250873 hasConcept C43617362 @default.
• W2767250873 hasConcept C52859227 @default.
• W2767250873 hasConcept C55493867 @default.
• W2767250873 hasConceptScore W2767250873C119128265 @default.
• W2767250873 hasConceptScore W2767250873C139369640 @default.
• W2767250873 hasConceptScore W2767250873C147789679 @default.
• W2767250873 hasConceptScore W2767250873C155672457 @default.
• W2767250873 hasConceptScore W2767250873C160756335 @default.
• W2767250873 hasConceptScore W2767250873C16387964 @default.
• W2767250873 hasConceptScore W2767250873C171250308 @default.
• W2767250873 hasConceptScore W2767250873C17525397 @default.
• W2767250873 hasConceptScore W2767250873C185592680 @default.
• W2767250873 hasConceptScore W2767250873C192562407 @default.
• W2767250873 hasConceptScore W2767250873C21951064 @default.
• W2767250873 hasConceptScore W2767250873C43617362 @default.
• W2767250873 hasConceptScore W2767250873C52859227 @default.
• W2767250873 hasConceptScore W2767250873C55493867 @default.
• W2767250873 hasFunder F4320321001 @default.
• W2767250873 hasLocation W27672508731 @default.
• W2767250873 hasLocation W27672508732 @default.
• W2767250873 hasOpenAccess W2767250873 @default.
• W2767250873 hasPrimaryLocation W27672508731 @default.
• W2767250873 hasRelatedWork W1995339385 @default.
• W2767250873 hasRelatedWork W2018870065 @default.
• W2767250873 hasRelatedWork W2034617980 @default.
• W2767250873 hasRelatedWork W2062675489 @default.

• next